{"id":"W2474397727","doi":"10.1124/dmd.116.070060","title":"Functional Integrity of the Chimeric (Humanized) Mouse Liver: Enzyme Zonation, Physiologic Spaces, and Hepatic Enzymes and Transporters","year":2016,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":13,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"In vivo; Sulfation; Perfusion; Glucuronidation; Albumin; Biology; Enzyme; Internal medicine; Chemistry; Endocrinology; Biochemistry; Microsome; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005688014,0.0004561681,0.0004320741,0.0004739934,0.000235841,0.0009784409,0.0004601603,0.0006450114,0.002719521],"category_scores_gemma":[0.0003464669,0.0002665074,0.0004265509,0.000290716,0.0008670003,0.000874939,0.0002580883,0.0009384557,0.0005248742],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004860418,"about_ca_system_score_gemma":0.00059458,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001455103,"about_ca_topic_score_gemma":0.001234106,"domain_scores_codex":[0.9996479,0.00005668087,0.00004840559,0.0000980841,0.00007996517,0.00006908612],"domain_scores_gemma":[0.9995887,0.00006429537,0.0001425786,0.00008260391,0.00005003944,0.00007177506],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007546967,0.00003270548,0.0003379183,0.00005001702,0.00002156198,0.0001005357,0.0000479052,0.0001538097,0.9953784,0.001669709,0.00007246546,0.001380384],"study_design_scores_gemma":[0.00002257845,0.0001001034,0.001192628,0.000003732651,0.00002779528,0.0003368476,0.00004031328,0.0006572547,0.9952548,0.0002005142,0.002157182,0.000006429607],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9709076,0.001698474,0.02227391,0.0006603808,0.0001198053,0.00004083556,0.001688152,0.0004679992,0.002142808],"genre_scores_gemma":[0.9877509,0.0004765032,0.006097965,0.0001183907,0.00001521636,0.00004006784,0.001138307,0.0001436895,0.004218933],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002719521,"threshold_uncertainty_score":0.009097695,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04095210611705749,"score_gpt":0.3114703662772778,"score_spread":0.2705182601602203,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}