{"id":"W2474604030","doi":"10.1016/j.neulet.2016.06.045","title":"Understanding the molecular mechanisms underlying mood stabilizer treatments in bipolar disorder: Potential involvement of epigenetics","year":2016,"lang":"en","type":"review","venue":"Neuroscience Letters","topic":"Bipolar Disorder and Treatment","field":"Medicine","cited_by":44,"is_retracted":false,"has_abstract":false,"ca_institutions":"Dalhousie University","funders":"","keywords":"Mood stabilizer; Mood; Epigenetics; Bipolar disorder; Lithium (medication); Mood disorders; Mechanism (biology); Psychology; Neuroscience; Medicine; Bioinformatics; Clinical psychology; Psychiatry; Gene; Biology; Genetics; Anxiety","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000229441,0.0005063008,0.001001237,0.0003585394,0.0001572706,0.00004321952,0.0004127279,0.0001527697,0.0000330785],"category_scores_gemma":[0.00004387111,0.0002904976,0.0004819958,0.0006571173,0.0002801975,0.00007760994,0.0001591442,0.0003133034,0.00001021916],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005231493,"about_ca_system_score_gemma":0.0002011523,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003916899,"about_ca_topic_score_gemma":0.00003086585,"domain_scores_codex":[0.9970231,0.0002527657,0.0006546469,0.0007320727,0.0007592218,0.0005782165],"domain_scores_gemma":[0.9987019,0.00009819898,0.0003345376,0.0007236728,0.00001943907,0.0001222714],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000628876,0.003285055,0.003378867,0.01158848,0.0007126285,0.000470838,0.0008295833,0.0001831694,0.03884527,0.004041925,0.00005193944,0.9365494],"study_design_scores_gemma":[0.01784287,0.005745862,0.0072576,0.05441114,0.01392783,0.0007229234,0.001154475,0.0004571356,0.002244817,0.006528927,0.8851621,0.004544307],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0005064038,0.9677956,0.02810382,0.0009873713,0.0003807854,0.002049487,0.0001101792,0.00003068334,0.00003571483],"genre_scores_gemma":[0.02802003,0.9710282,0.0001537245,0.000510819,0.0000127396,0.0001425493,0.00003780934,0.00007287116,0.00002125595],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.932005,"threshold_uncertainty_score":0.9999547,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1121877601997052,"score_gpt":0.3285101428489796,"score_spread":0.2163223826492744,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}