{"id":"W2474805563","doi":"10.1002/pbc.26118","title":"Outcome of young children with high‐grade glioma treated with irradiation‐avoiding intensive chemotherapy regimens: Final report of the Head Start II and III trials","year":2016,"lang":"en","type":"article","venue":"Pediatric Blood & Cancer","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital","funders":"Hope Foundation; National Cancer Institute; Maddie's Fund; Alex's Lemonade Stand Foundation for Childhood Cancer; Pediatric Cancer Research Foundation","keywords":"Medicine; Carboplatin; Chemotherapy; Anaplastic astrocytoma; Vincristine; Temozolomide; Regimen; Induction chemotherapy; Internal medicine; Glioma; Radiation therapy; Chemotherapy regimen; Surgery; Oncology; Gastroenterology; Astrocytoma; Cisplatin; Cyclophosphamide; Cancer research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002290749,0.000561456,0.001103673,0.0002052704,0.0002521827,0.0006679021,0.0004227266,0.0004687318,0.0006346391],"category_scores_gemma":[0.001370787,0.0001689723,0.001186248,0.0003721551,0.0004495905,0.0003813872,0.0003210262,0.0009389373,0.0001424715],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009420181,"about_ca_system_score_gemma":0.001647729,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002110601,"about_ca_topic_score_gemma":0.005868144,"domain_scores_codex":[0.999204,0.0005034055,0.00006021061,0.00005189078,0.00008906217,0.00009147304],"domain_scores_gemma":[0.9987293,0.0003100149,0.0004877842,0.00009479532,0.00009354245,0.0002845122],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5483731,0.0109766,0.2223614,0.002716376,0.008158347,0.0005592983,0.0007572474,0.0034412,0.007691002,0.0003517493,0.00719042,0.1874234],"study_design_scores_gemma":[0.1914763,0.3543257,0.4200588,0.0006874845,0.007125558,0.001391393,0.0006429889,0.001255679,0.007510363,0.0003603967,0.01508771,0.00007757166],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.988519,0.008068833,0.000284021,0.0002668385,0.00005025758,0.0006570624,0.001104093,0.00001842489,0.001031442],"genre_scores_gemma":[0.985855,0.006998335,0.0008707398,0.0007838015,0.000143484,0.001254492,0.003475399,0.00001724305,0.0006014772],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002290749,"threshold_uncertainty_score":0.01211482,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03576731847219498,"score_gpt":0.2951498172602274,"score_spread":0.2593824987880324,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}