{"id":"W2474805563","doi":"10.1002/pbc.26118","title":"Outcome of young children with high‐grade glioma treated with irradiation‐avoiding intensive chemotherapy regimens: Final report of the Head Start II and III trials","year":2016,"lang":"en","type":"article","venue":"Pediatric Blood & Cancer","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital","funders":"Hope Foundation; National Cancer Institute; Maddie's Fund; Alex's Lemonade Stand Foundation for Childhood Cancer; Pediatric Cancer Research Foundation","keywords":"Medicine; Carboplatin; Chemotherapy; Anaplastic astrocytoma; Vincristine; Temozolomide; Regimen; Induction chemotherapy; Internal medicine; Glioma; Radiation therapy; Chemotherapy regimen; Surgery; Oncology; Gastroenterology; Astrocytoma; Cisplatin; Cyclophosphamide; Cancer research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003567609,0.0002515444,0.0008811695,0.0001748736,0.0001087463,0.00000759251,0.00007632983,0.00007804842,0.00004920101],"category_scores_gemma":[0.0001863719,0.0001103291,0.0001240819,0.0005020912,0.0001187834,0.00007343983,0.0000301232,0.00009867552,3.588033e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006978091,"about_ca_system_score_gemma":0.0001854842,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002801974,"about_ca_topic_score_gemma":0.0002174827,"domain_scores_codex":[0.9982188,0.00008261041,0.0006799998,0.0003650946,0.0004169032,0.0002366455],"domain_scores_gemma":[0.9980205,0.0001922867,0.0008827354,0.0004278439,0.0003772267,0.00009934856],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007736238,0.0003927145,0.9931133,0.00004341836,0.001073675,0.00007533542,0.000304639,0.000003232002,0.003282064,0.00002601092,0.0004496772,0.0004622876],"study_design_scores_gemma":[0.02187542,0.001248615,0.9252825,0.0002336298,0.003605079,0.0006649977,0.00006117704,0.000001026215,0.04682172,0.00001548967,0.00003362332,0.0001566667],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992968,0.002666511,0.000006235561,0.003113411,0.00007526282,0.001029048,0.00009118985,0.00002538861,0.00002495693],"genre_scores_gemma":[0.9978069,0.001246444,0.0001862868,0.0001175949,0.0002969119,0.0001271138,0.00001068738,0.00003365077,0.0001743911],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06783076,"threshold_uncertainty_score":0.449909,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03576731847219498,"score_gpt":0.2951498172602274,"score_spread":0.2593824987880324,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}