{"id":"W2474916704","doi":"10.1182/blood-2016-02-699561","title":"Polyphosphate is a novel cofactor for regulation of complement by a serpin, C1 inhibitor","year":2016,"lang":"en","type":"article","venue":"Blood","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research","keywords":"Cofactor; Serpin; Colocalization; C1-inhibitor; Regulator; Biochemistry; Chemistry; Complement (music); Platelet; Heparin cofactor II; Function (biology); Antithrombin; Biology; Heparin; Cell biology; Immunology; Enzyme; Phenotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001398748,0.0001773166,0.0003463183,0.00007204251,0.00006589689,0.00001019462,0.00007382531,0.00008878272,0.0004990461],"category_scores_gemma":[0.00006555772,0.0001294694,0.0001680743,0.0001209343,0.00006514853,0.0001021982,0.00003013036,0.00002965301,0.00001635907],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003487169,"about_ca_system_score_gemma":0.00008721879,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007969297,"about_ca_topic_score_gemma":0.000009128878,"domain_scores_codex":[0.9986645,0.000009595025,0.0004694419,0.0002885051,0.0002875478,0.0002804328],"domain_scores_gemma":[0.9990392,0.0001084976,0.0002280898,0.0002889843,0.0001994734,0.0001356999],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004699661,0.001462364,0.06117259,0.0002314712,0.0003282004,8.313793e-7,0.0006360456,3.893276e-7,0.8943469,0.002792738,0.0291774,0.009381091],"study_design_scores_gemma":[0.01618276,0.0007080252,0.09081087,0.0004640306,0.000340533,0.00001183667,0.0000550639,0.0001436139,0.8418297,0.0004165182,0.04878945,0.0002476224],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9823055,0.001598449,0.007901361,0.005401157,0.0002254799,0.001329776,0.0009424633,0.0001031602,0.0001926676],"genre_scores_gemma":[0.9939465,0.00003692523,0.002130308,0.0004412285,0.0002425291,0.00005299985,0.000107403,0.00003629094,0.00300582],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05251724,"threshold_uncertainty_score":0.5464205,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0224059603147807,"score_gpt":0.2661058648048552,"score_spread":0.2436999044900744,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}