{"id":"W2474933363","doi":"10.1101/gad.280222.116","title":"The Nrd1-like protein Seb1 coordinates cotranscriptional 3′ end processing and polyadenylation site selection","year":2016,"lang":"en","type":"article","venue":"Genes & Development","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; University College London; Imperial College London; McGill University; Génome Québec; Wellcome Trust; National Institute of General Medical Sciences; Medical Research Council; Wellcome","keywords":"Polyadenylation; Biology; Cleavage and polyadenylation specificity factor; Post-transcriptional modification; RNA polymerase II; Genetics; Three prime untranslated region; Schizosaccharomyces pombe; RNA; Untranslated region; Terminator (solar); Cleavage factor; Transcription (linguistics); Cell biology; RNA-binding protein; Gene; Saccharomyces cerevisiae; Gene expression; Promoter","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000916171,0.0003746075,0.0002260278,0.0002073293,0.0001988082,0.0003641656,0.0002184784,0.0002483662,0.001485674],"category_scores_gemma":[0.0001181899,0.0002571121,0.000178608,0.0001313445,0.0002566443,0.0001705534,0.0004209332,0.0005170226,0.001269679],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003920702,"about_ca_system_score_gemma":0.0001863963,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007198365,"about_ca_topic_score_gemma":0.00177231,"domain_scores_codex":[0.9998499,0.00001566292,0.000008033692,0.00006034004,0.00004047695,0.00002550615],"domain_scores_gemma":[0.9998862,0.00001387198,0.00002822985,0.00001112166,0.00001270798,0.0000477938],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003972211,0.000005231035,0.0002002277,0.000009025007,0.000001000179,0.00002628122,0.000005800087,0.00002600376,0.9990417,0.00006677111,0.00002518694,0.0005530749],"study_design_scores_gemma":[0.00001416744,0.00004786214,0.01554545,0.000006220029,0.000004711218,0.0002979111,0.00003448341,0.001753308,0.9794057,0.0001149671,0.002769474,0.000005719011],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9844988,0.002336597,0.009849226,0.000137214,0.00005551315,0.0000153243,0.0007059799,0.0002579885,0.002143394],"genre_scores_gemma":[0.9879953,0.0005906364,0.004649179,0.00004114368,0.000006439472,0.00001817297,0.001209974,0.00007477869,0.005414353],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001485674,"threshold_uncertainty_score":0.004970074,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008659688274376704,"score_gpt":0.2354125311898468,"score_spread":0.2267528429154701,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}