{"id":"W2474933363","doi":"10.1101/gad.280222.116","title":"The Nrd1-like protein Seb1 coordinates cotranscriptional 3′ end processing and polyadenylation site selection","year":2016,"lang":"en","type":"article","venue":"Genes & Development","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; University College London; Imperial College London; McGill University; Génome Québec; Wellcome Trust; National Institute of General Medical Sciences; Medical Research Council; Wellcome","keywords":"Polyadenylation; Biology; Cleavage and polyadenylation specificity factor; Post-transcriptional modification; RNA polymerase II; Genetics; Three prime untranslated region; Schizosaccharomyces pombe; RNA; Untranslated region; Terminator (solar); Cleavage factor; Transcription (linguistics); Cell biology; RNA-binding protein; Gene; Saccharomyces cerevisiae; Gene expression; Promoter","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002291635,0.00009331157,0.00005251924,0.00002618785,0.000393901,0.00005774811,0.00006433179,0.00005674062,0.000009246866],"category_scores_gemma":[0.00001921472,0.0000561912,0.00001642827,0.00005577459,0.00005944667,0.000008536597,0.00004232274,0.00003463397,0.000007441108],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002984696,"about_ca_system_score_gemma":0.0001725936,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001358291,"about_ca_topic_score_gemma":0.0001460174,"domain_scores_codex":[0.9992302,0.00003405047,0.0001329964,0.000212969,0.0001622074,0.0002275518],"domain_scores_gemma":[0.9997323,0.000007998299,0.00003812403,0.00006420102,0.00009831562,0.00005907256],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004811543,0.000006541483,0.005316172,0.000009539209,0.00001503405,3.260478e-7,0.00003975042,0.000001282418,0.8111426,0.00002616275,0.0001115025,0.183283],"study_design_scores_gemma":[0.0003379235,0.00006014605,0.04666804,0.00003414516,0.000003054196,0.00001435494,0.00002928708,0.00006786714,0.8766274,0.00004634682,0.0759813,0.0001301739],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904199,0.002061427,0.00644285,0.0007670366,0.00003615783,0.0002072075,0.000002275433,0.00001145261,0.0000517486],"genre_scores_gemma":[0.9923653,0.0002506686,0.001575791,0.00004442692,0.00008340165,0.0000737266,0.00002249533,0.00001075625,0.005573418],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1831529,"threshold_uncertainty_score":0.3029608,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008659688274376704,"score_gpt":0.2354125311898468,"score_spread":0.2267528429154701,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}