{"id":"W2474981734","doi":"10.1038/ncomms11934","title":"Early role of vascular dysregulation on late-onset Alzheimer’s disease based on multifactorial data-driven analysis","year":2016,"lang":"en","type":"article","venue":"Nature Communications","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":1202,"is_retracted":false,"has_abstract":true,"ca_institutions":"St Joseph's Health Centre; Sunnybrook Health Science Centre; Jewish General Hospital; University of Calgary; McGill University; Douglas Mental Health University Institute; St Joseph's Health Care; Montreal Neurological Institute and Hospital","funders":"National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Azrieli Foundation; Eisai; Northern California Institute for Research and Education; University of California, San Diego; Fondation Brain Canada; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; University of Southern California; Eli Lilly and Company; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Bristol-Myers Squibb; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Abnormality; Disease; Neuroimaging; Neuroscience; Pathological; Medicine; Alzheimer's disease; Amyloid (mycology); Psychology; Pathology; Psychiatry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004094104,0.000757765,0.0005562622,0.002099843,0.0003080792,0.001254329,0.0004241815,0.0003739999,0.0008092437],"category_scores_gemma":[0.00620937,0.0001636778,0.001200498,0.001140131,0.0004435329,0.000766173,0.0007829962,0.0004526374,0.0001648889],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004087783,"about_ca_system_score_gemma":0.0005697162,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002781398,"about_ca_topic_score_gemma":0.002835752,"domain_scores_codex":[0.9989748,0.0004444138,0.00008154622,0.0002624358,0.0001382184,0.00009856183],"domain_scores_gemma":[0.9956228,0.00264102,0.0006635712,0.0005180508,0.0003715713,0.00018293],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008677003,0.0001653816,0.884333,0.0001777303,0.0009788453,0.0004909546,0.0003719025,0.01444703,0.02058731,0.001162912,0.0006189161,0.07579832],"study_design_scores_gemma":[0.00001409239,0.0002405129,0.8473759,0.00004133909,0.0004147927,0.0005544873,0.0002191933,0.1385698,0.005997341,0.005454341,0.001065512,0.00005271471],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9526498,0.001168407,0.0438164,0.000261528,0.00002299854,0.00004083968,0.001260736,0.0002160716,0.0005631973],"genre_scores_gemma":[0.9932886,0.0001163065,0.005697848,0.00001838152,0.00001044262,0.00001446701,0.000727644,0.00001384725,0.0001124841],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004094104,"threshold_uncertainty_score":0.02165198,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04603176532185266,"score_gpt":0.3559460956345858,"score_spread":0.3099143303127331,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}