{"id":"W2475144282","doi":"10.1021/acs.inorgchem.5b00921","title":"Cyclometalated Iridium(III) Imidazole Phenanthroline Complexes as Luminescent and Electrochemiluminescent G-Quadruplex DNA Binders","year":2015,"lang":"en","type":"article","venue":"Inorganic Chemistry","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Canada Foundation for Innovation; Research Corporation for Science Advancement","keywords":"Chemistry; G-quadruplex; Iridium; Imidazole; Luminescence; Phenanthroline; Chemiluminescence; DNA; Ligand (biochemistry); Guanine; Combinatorial chemistry; Luminescent Measurements; Photochemistry; Stereochemistry; Crystallography; Biochemistry; Nucleotide; Organic chemistry; Receptor; Catalysis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002588108,0.0002863475,0.0002732333,0.0002500778,0.000152384,0.0003935236,0.0007615663,0.0003838908,0.0009251852],"category_scores_gemma":[0.000332147,0.0002025276,0.00009580979,0.0002390168,0.000295408,0.0002210314,0.0002215896,0.000299628,0.0002461199],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005453359,"about_ca_system_score_gemma":0.000161226,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007011717,"about_ca_topic_score_gemma":0.001202529,"domain_scores_codex":[0.9996766,0.00006922892,0.00002316341,0.00007935772,0.0000983401,0.00005344456],"domain_scores_gemma":[0.9998757,0.00002067756,0.00003388332,0.00001414033,0.00002768423,0.00002802946],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001508156,0.00002513665,0.0001286444,0.00003838775,0.00000479952,0.00002462777,0.00002428057,0.0001921611,0.9967335,0.0001342064,0.00007662208,0.002466913],"study_design_scores_gemma":[0.00001790334,0.0001117293,0.0004765981,0.000001670679,0.000007231419,0.0000671584,0.00000659949,0.001070077,0.9972839,0.00001426126,0.0009385905,0.000004231741],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9871651,0.00145956,0.009296997,0.0001030703,0.00002609209,0.00004029046,0.0001081652,0.000368951,0.001431766],"genre_scores_gemma":[0.9907805,0.0003077579,0.006092628,0.00003156695,0.000007650489,0.00002665762,0.0001777341,0.00002671595,0.00254867],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009251852,"threshold_uncertainty_score":0.003956735,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008697111361899193,"score_gpt":0.2313795182012945,"score_spread":0.2226824068393953,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}