{"id":"W2475144282","doi":"10.1021/acs.inorgchem.5b00921","title":"Cyclometalated Iridium(III) Imidazole Phenanthroline Complexes as Luminescent and Electrochemiluminescent G-Quadruplex DNA Binders","year":2015,"lang":"en","type":"article","venue":"Inorganic Chemistry","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Canada Foundation for Innovation; Research Corporation for Science Advancement","keywords":"Chemistry; G-quadruplex; Iridium; Imidazole; Luminescence; Phenanthroline; Chemiluminescence; DNA; Ligand (biochemistry); Guanine; Combinatorial chemistry; Luminescent Measurements; Photochemistry; Stereochemistry; Crystallography; Biochemistry; Nucleotide; Organic chemistry; Receptor; Catalysis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001618227,0.0004951986,0.0003994748,0.00002704598,0.0001143543,0.00006002147,0.0004248476,0.0004134148,0.0002215062],"category_scores_gemma":[0.0002152851,0.0004988717,0.0001250995,0.000225253,0.0003406152,0.00001148319,0.0003708741,0.0002664633,0.00003716883],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009161792,"about_ca_system_score_gemma":0.0003024952,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004713283,"about_ca_topic_score_gemma":0.000005700649,"domain_scores_codex":[0.9977074,0.00001977751,0.0004598203,0.0008157617,0.000352942,0.0006442447],"domain_scores_gemma":[0.9983397,0.00001427606,0.0001910589,0.0006950287,0.0002078878,0.0005520412],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001842104,0.0001765514,0.0007456036,0.00009280428,0.0001212523,0.00002077416,0.00008827273,0.000002492309,0.9893782,0.000003230825,0.009005799,0.0001808268],"study_design_scores_gemma":[0.001911174,0.00007929947,0.000123769,0.00003475097,0.00007075185,0.0004362281,0.0005548489,0.00005720726,0.9795967,0.00003762466,0.01650881,0.0005888592],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930521,0.001584452,0.00004536485,0.0004198123,0.0001163065,0.000159822,0.00002248897,0.00009358773,0.004506014],"genre_scores_gemma":[0.9960929,0.0003364857,0.00009742526,0.0003563587,0.000612286,0.00001750417,0.0005114092,0.00008310129,0.001892525],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009781511,"threshold_uncertainty_score":0.9997463,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008697111361899193,"score_gpt":0.2313795182012945,"score_spread":0.2226824068393953,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}