{"id":"W2475147046","doi":"10.1371/journal.pone.0158242","title":"Donor-Recipient Matching for KIR Genotypes Reduces Chronic GVHD and Missing Inhibitory KIR Ligands Protect against Relapse after Myeloablative, HLA Matched Hematopoietic Cell Transplantation","year":2016,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Calgary Laboratory Services; Foothills Medical Centre; Alberta Children's Hospital; University of Calgary","funders":"Alberta Innovates; Alberta Innovates - Health Solutions; Alberta Cancer Foundation; American College Health Foundation; Children's Hospital Foundation; Alberta Children's Hospital Foundation; Calgary Laboratory Services; American Society of Hematology","keywords":"Medicine; Human leukocyte antigen; Hematopoietic stem cell transplantation; Proportional hazards model; Transplantation; Immunology; Graft-versus-host disease; Hazard ratio; Sibling; Internal medicine; Oncology; Cohort; Confidence interval; Antigen","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007209724,0.000147339,0.0003388168,0.0001239746,0.0001165168,0.0003111099,0.0001930911,0.0001241574,0.001760626],"category_scores_gemma":[0.0008273913,0.00005341069,0.0002820661,0.0001345107,0.0001540146,0.0001310363,0.0002005002,0.0003503245,0.0001855036],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001066997,"about_ca_system_score_gemma":0.0002253588,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001282177,"about_ca_topic_score_gemma":0.0001715397,"domain_scores_codex":[0.999773,0.00007345055,0.0000180668,0.00004625802,0.00004568279,0.00004358875],"domain_scores_gemma":[0.9994251,0.00009885973,0.000217139,0.00007799891,0.00002242306,0.0001585017],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.04418759,0.005554672,0.6900061,0.0002475165,0.0009027523,0.0002772895,0.000243375,0.001634848,0.1076565,0.0005544092,0.001555971,0.1471789],"study_design_scores_gemma":[0.0004939913,0.02070057,0.95423,0.00005585163,0.0005657637,0.0009230133,0.0001183718,0.002503049,0.01817903,0.0004416048,0.001775848,0.00001289635],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.999286,0.0002605191,0.0002104116,0.00002373657,0.000008361995,0.000007809251,0.00004086759,0.000008071124,0.000154309],"genre_scores_gemma":[0.9995949,0.00006782929,0.00009562598,0.00002032237,0.000004608065,0.00000586016,0.00007792353,0.000002036155,0.0001309314],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001760626,"threshold_uncertainty_score":0.005889893,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01540590534489338,"score_gpt":0.2070212103415874,"score_spread":0.191615304996694,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}