{"id":"W2475682196","doi":"10.1038/srep30953","title":"microRNA-132/212 deficiency enhances Aβ production and senile plaque deposition in Alzheimer’s disease triple transgenic mice","year":2016,"lang":"en","type":"article","venue":"Scientific Reports","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":151,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Canadian Institutes of Health Research; Institut National de la Santé et de la Recherche Médicale; Alzheimer Society","keywords":"Genetically modified mouse; Senile plaques; microRNA; Transgene; Alzheimer's disease; Biology; Disease; Gene; Cell biology; Medicine; Genetics; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001862833,0.0008055627,0.0006815994,0.0006611859,0.0002779613,0.0005087613,0.0002369339,0.0005007877,0.002020705],"category_scores_gemma":[0.0001540137,0.0003954089,0.000566651,0.0003086228,0.0003635222,0.0002270825,0.0002497206,0.0009340832,0.0007348071],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003175724,"about_ca_system_score_gemma":0.000261744,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000717069,"about_ca_topic_score_gemma":0.001223892,"domain_scores_codex":[0.9997333,0.00002107346,0.00003221693,0.00008472447,0.00008639188,0.00004230053],"domain_scores_gemma":[0.9997029,0.0000282127,0.0001301746,0.00001464327,0.00002368865,0.000100359],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002985726,0.0000606818,0.0002471376,0.00004242162,0.00001766682,0.000100721,0.0000222233,0.0000603967,0.9981114,0.00006091517,0.00007523943,0.0009028231],"study_design_scores_gemma":[0.0001474375,0.001366292,0.02199186,0.00003514133,0.0002049112,0.001285152,0.0001228794,0.003181459,0.9663863,0.0003331697,0.004905164,0.00004022354],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924126,0.00067439,0.003250476,0.0001549212,0.00007411753,0.00005041845,0.001655416,0.0004628451,0.001264941],"genre_scores_gemma":[0.9843997,0.001044079,0.006329708,0.0002462362,0.00003636319,0.0001764235,0.001957973,0.0002479363,0.005561558],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002020705,"threshold_uncertainty_score":0.006759942,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01003751945772466,"score_gpt":0.2404345771150911,"score_spread":0.2303970576573665,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}