{"id":"W2475982136","doi":"10.1200/jco.2015.33.15_suppl.5506","title":"An international, biomarker-directed, randomized, phase II trial of AZD1775 plus paclitaxel and carboplatin (P/C) for the treatment of women with platinum-sensitive, <i>TP53</i>-mutant ovarian cancer.","year":2015,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Centre Hospitalier de l’Université de Montréal; Ottawa Hospital; University Health Network","funders":"","keywords":"Medicine; Tolerability; Internal medicine; Carboplatin; Urology; Cancer; Gastroenterology; Nuclear medicine; Surgery; Chemotherapy; Adverse effect; Cisplatin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001504368,0.00185447,0.001584947,0.0004564716,0.0004121605,0.000871854,0.000962844,0.001380723,0.005539599],"category_scores_gemma":[0.001088653,0.0006564733,0.00095773,0.000468581,0.001006301,0.0008094852,0.0004930146,0.00251787,0.001130222],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001195023,"about_ca_system_score_gemma":0.002043332,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001173472,"about_ca_topic_score_gemma":0.003378113,"domain_scores_codex":[0.9995418,0.0002472045,0.00002369735,0.00008005007,0.0000356104,0.00007164224],"domain_scores_gemma":[0.9995016,0.00007103997,0.0001137134,0.00004036603,0.00002567071,0.0002476764],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9388871,0.01491579,0.00250068,0.0004649479,0.0008097996,0.0001088409,0.0001070686,0.0005882189,0.009950543,0.0002000784,0.002326594,0.0291403],"study_design_scores_gemma":[0.9042097,0.08893426,0.003416284,0.00001786116,0.0003511294,0.0000919148,0.00002356873,0.0003168183,0.0007898593,0.0001022047,0.00173435,0.00001201122],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9786725,0.003908697,0.0006792069,0.001144022,0.0003285411,0.00870177,0.002387985,0.0001173605,0.004059965],"genre_scores_gemma":[0.9784691,0.00265528,0.002243052,0.001819165,0.0003734083,0.006632982,0.003808442,0.00002977512,0.003968872],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005539599,"threshold_uncertainty_score":0.0185318,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1106442141271317,"score_gpt":0.4511448396080807,"score_spread":0.340500625480949,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}