{"id":"W2475982136","doi":"10.1200/jco.2015.33.15_suppl.5506","title":"An international, biomarker-directed, randomized, phase II trial of AZD1775 plus paclitaxel and carboplatin (P/C) for the treatment of women with platinum-sensitive, <i>TP53</i>-mutant ovarian cancer.","year":2015,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Centre Hospitalier de l’Université de Montréal; Ottawa Hospital; University Health Network","funders":"","keywords":"Medicine; Tolerability; Internal medicine; Carboplatin; Urology; Cancer; Gastroenterology; Nuclear medicine; Surgery; Chemotherapy; Adverse effect; Cisplatin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004668021,0.0001998281,0.002559039,0.0001451135,0.00004439584,0.000007591909,0.0001394032,0.0002900712,0.00002645577],"category_scores_gemma":[0.003444631,0.0001077525,0.0003928441,0.0001494659,0.0005854619,0.00008625286,0.00002557258,0.0002994415,1.689811e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007272008,"about_ca_system_score_gemma":0.003509405,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003359597,"about_ca_topic_score_gemma":0.0001775056,"domain_scores_codex":[0.9960389,0.0006450232,0.002382959,0.0002289853,0.0004653035,0.0002388873],"domain_scores_gemma":[0.991036,0.004201966,0.002946605,0.0002603797,0.001114462,0.0004406017],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8827297,0.004206214,0.0001169975,0.00001602149,0.003210795,0.0001735172,0.002061756,0.0001539485,0.002461239,0.00006224732,0.0001620539,0.1046455],"study_design_scores_gemma":[0.8549508,0.1225984,0.000344434,0.0001403801,0.001687337,0.0002706831,0.0007233061,0.00580382,0.001320689,0.0001058838,0.01195088,0.0001033539],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912811,0.0007812772,0.001345607,0.002650848,0.001687303,0.001682495,0.00009303004,0.000009980266,0.0004683803],"genre_scores_gemma":[0.9931498,0.002122378,0.003464964,0.0002025833,0.000888449,0.00009353033,0.000009104708,0.00002606652,0.00004307807],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1183922,"threshold_uncertainty_score":0.6225534,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1106442141271317,"score_gpt":0.4511448396080807,"score_spread":0.340500625480949,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}