{"id":"W2476275359","doi":"10.1158/1538-7445.am2016-ct034","title":"Abstract CT034: A phase I study of GSK2857916, a BCMA-directed monoclonal antibody conjugated to microtubule-disrupting agent in patients with relapsed, refractory multiple myeloma and other BCMA-expressing hematologic malignancies","year":2016,"lang":"en","type":"article","venue":"Cancer Research","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Vancouver General Hospital","funders":"","keywords":"Medicine; Multiple myeloma; Antibody; Tolerability; Immunogenicity; Pharmacology; Cancer research; Monoclonal antibody; Immunology; Internal medicine; Oncology; Adverse effect","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006098549,0.001444396,0.00151173,0.0004533292,0.0003558297,0.0007893904,0.001053087,0.001114265,0.004920741],"category_scores_gemma":[0.0003777089,0.0004509986,0.001103393,0.000454107,0.000664762,0.0005702551,0.0002707971,0.002726612,0.001379942],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001105339,"about_ca_system_score_gemma":0.001368555,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002135785,"about_ca_topic_score_gemma":0.004792796,"domain_scores_codex":[0.9998004,0.00005452584,0.0000123856,0.00005239135,0.00003215451,0.00004814955],"domain_scores_gemma":[0.9997568,0.00002373559,0.00004304531,0.00002290705,0.00001986314,0.0001336962],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.3042646,0.08183579,0.008937936,0.003226806,0.003100085,0.001654578,0.0006455583,0.006173004,0.3261405,0.001478717,0.01871845,0.243824],"study_design_scores_gemma":[0.3906727,0.559054,0.01501898,0.000117774,0.0008827255,0.001645436,0.0001047818,0.002566759,0.02021782,0.000307533,0.009356986,0.00005451792],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9845895,0.004397909,0.00104033,0.0006714998,0.000184507,0.002673862,0.002025599,0.0002759033,0.0041409],"genre_scores_gemma":[0.981697,0.002995713,0.0017099,0.001129693,0.0001193904,0.002413565,0.003659964,0.00005042212,0.00622439],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004920741,"threshold_uncertainty_score":0.01646155,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06872917316155,"score_gpt":0.4033111929284408,"score_spread":0.3345820197668907,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}