{"id":"W2477245600","doi":"10.1200/jco.2016.34.15_suppl.9513","title":"KEYNOTE-006 study of pembrolizumab (pembro) versus ipilimumab (ipi) for advanced melanoma: Efficacy by PD-L1 expression and line of therapy.","year":2016,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; McMaster University; Juravinski Cancer Centre","funders":"","keywords":"Pembrolizumab; Medicine; Ipilimumab; Internal medicine; Oncology; Family medicine; Immunotherapy; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002165623,0.001182939,0.001486269,0.0002965904,0.0002539268,0.001053661,0.0009975942,0.001317326,0.01034407],"category_scores_gemma":[0.00144166,0.0006129649,0.001579815,0.0004100298,0.0005956398,0.001198254,0.000530325,0.003431557,0.001512235],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001160263,"about_ca_system_score_gemma":0.0009007977,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004763957,"about_ca_topic_score_gemma":0.001581165,"domain_scores_codex":[0.9993537,0.0003348821,0.00004440292,0.0001123636,0.00006652528,0.00008810353],"domain_scores_gemma":[0.9992854,0.0001554332,0.000244423,0.0000465329,0.0000382985,0.0002298048],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9287276,0.007587473,0.003943805,0.001572162,0.001867029,0.00007671261,0.00009840865,0.001029285,0.01163697,0.0003584679,0.003541859,0.03956025],"study_design_scores_gemma":[0.7976268,0.1750786,0.01433257,0.0001557814,0.001979483,0.0002745258,0.00004997512,0.0009602537,0.001870527,0.0003556609,0.007281973,0.00003393953],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9648582,0.01239895,0.001125293,0.001214459,0.0004941215,0.004315848,0.006410778,0.0001495816,0.009032764],"genre_scores_gemma":[0.9791778,0.003796497,0.001237206,0.001444758,0.0003366724,0.002466917,0.003907841,0.00003616981,0.007596123],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01034407,"threshold_uncertainty_score":0.03460431,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.111405916422775,"score_gpt":0.4643476528672035,"score_spread":0.3529417364444285,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}