{"id":"W2477687688","doi":"10.1128/jvi.01107-16","title":"Novel Acylguanidine-Based Inhibitor of HIV-1","year":2016,"lang":"en","type":"article","venue":"Journal of Virology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"AIDS Vancouver; University of British Columbia; Université de Montréal; Simon Fraser University","funders":"Canadian Institutes of Health Research","keywords":"Tetherin; Biology; Infectivity; Viral replication; Virology; Reverse transcriptase; Integrase inhibitor; Protease; In vitro; Extracellular; Integrase; Virus; Viral load; Human immunodeficiency virus (HIV); Cell biology; RNA; Enzyme; Antiretroviral therapy; Genetics; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006215799,0.0003327533,0.0001828421,0.00007612135,0.00009656715,0.0001266469,0.00034964,0.0002962818,0.001031784],"category_scores_gemma":[0.00006197758,0.00006045871,0.0001502358,0.00007074362,0.0001198249,0.0001202775,0.0001835877,0.0003037329,0.0003495424],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002054548,"about_ca_system_score_gemma":0.0001384953,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000298835,"about_ca_topic_score_gemma":0.0006167561,"domain_scores_codex":[0.9999528,0.000008653236,0.00000413472,0.000009609349,0.00001211053,0.00001261567],"domain_scores_gemma":[0.9999739,0.000004427285,0.000006796501,0.000002656279,0.000004838571,0.000007352135],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002330709,0.00007351209,0.0002828899,0.0001623835,0.00001011567,0.0001486738,0.00001756708,0.0002722531,0.9837984,0.00037672,0.0001669759,0.01445749],"study_design_scores_gemma":[0.0001257275,0.003033815,0.002058828,0.00001907702,0.00003622948,0.001244775,0.00001353524,0.001979997,0.9747154,0.0001057221,0.01665573,0.00001118955],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9719757,0.01444401,0.005796707,0.0002454476,0.0001247075,0.0001429337,0.000257678,0.0001761909,0.006836677],"genre_scores_gemma":[0.9787732,0.005767249,0.01026894,0.0002020588,0.00005014802,0.0000929758,0.0005268166,0.00001612329,0.004302482],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001031784,"threshold_uncertainty_score":0.003451645,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01700978090978045,"score_gpt":0.2635628391937793,"score_spread":0.2465530582839988,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}