{"id":"W2477923971","doi":"10.1089/scd.2015.0389","title":"Glutamate Increases In Vitro Survival and Proliferation and Attenuates Oxidative Stress-Induced Cell Death in Adult Spinal Cord-Derived Neural Stem/Progenitor Cells via Non-NMDA Ionotropic Glutamate Receptors","year":2016,"lang":"en","type":"article","venue":"Stem Cells and Development","topic":"Neurogenesis and neuroplasticity mechanisms","field":"Neuroscience","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Krembil Foundation","keywords":"Kainate receptor; AMPA receptor; Excitotoxicity; Glutamate receptor; Biology; NMDA receptor; Neural stem cell; Progenitor cell; Kainic acid; Cell biology; Neuroprotection; Ionotropic effect; Oxidative stress; Pharmacology; Stem cell; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001743642,0.000492223,0.0005190871,0.0002912234,0.0001569303,0.0003107364,0.0002447774,0.0002468937,0.001058752],"category_scores_gemma":[0.00009012187,0.0001299812,0.0003719614,0.0002385651,0.0001891403,0.0002223563,0.0002286808,0.0006954644,0.0003117349],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001851989,"about_ca_system_score_gemma":0.0002943832,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001331697,"about_ca_topic_score_gemma":0.00331675,"domain_scores_codex":[0.9998312,0.00002127419,0.00003457499,0.00002441491,0.00005431416,0.00003417586],"domain_scores_gemma":[0.9999247,0.000007780675,0.00002145168,0.000007809943,0.00001517104,0.00002312746],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003268839,0.0001761482,0.000235744,0.0001292366,0.00001734438,0.00008302151,0.00006196582,0.00009926125,0.9960588,0.00004240655,0.00007301379,0.002696246],"study_design_scores_gemma":[0.00003996543,0.001530557,0.00703362,0.000019961,0.00004908075,0.0001305066,0.00008072878,0.0004541893,0.9888016,0.00003198931,0.001823101,0.000004785287],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924486,0.004063688,0.001185734,0.0001298899,0.00004736609,0.00003125684,0.0003855437,0.00006117505,0.001646877],"genre_scores_gemma":[0.9893442,0.004237086,0.001852352,0.0001178344,0.00002565286,0.0000908346,0.001099079,0.00001894347,0.003213922],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001331697,"threshold_uncertainty_score":0.003541887,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02723922054901278,"score_gpt":0.2358043349645595,"score_spread":0.2085651144155467,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}