{"id":"W2478393974","doi":"10.1016/j.bmc.2016.07.038","title":"Effects of stereochemistry, saturation, and hydrocarbon chain length on the ability of synthetic constrained azacyclic sphingolipids to trigger nutrient transporter down-regulation, vacuolation, and cell death","year":2016,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"National Institute of General Medical Sciences; Congressionally Directed Medical Research Programs; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; National Cancer Institute; University of California, Irvine; American Cancer Society","keywords":"Chemistry; Sphingolipid; Ceramide; Sphingosine; Transporter; Biochemistry; Cytoplasm; Cytotoxicity; Programmed cell death; Stereochemistry; Cancer cell; Cell biology; In vitro; Biology; Gene; Receptor; Cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001346789,0.0002160207,0.0001264748,0.0001087896,0.0000789307,0.0001452771,0.0001496592,0.0001278274,0.001133246],"category_scores_gemma":[0.0002000487,0.00009178516,0.00007701696,0.000158163,0.0001655121,0.0001922227,0.0001054754,0.0001873758,0.0001491884],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001913727,"about_ca_system_score_gemma":0.0002159712,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007825739,"about_ca_topic_score_gemma":0.001658012,"domain_scores_codex":[0.9999348,0.0000157515,0.000007468462,0.00001187622,0.00001331453,0.00001670469],"domain_scores_gemma":[0.9998171,0.00006629216,0.00004804838,0.00001348882,0.00002082265,0.00003428471],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008623285,0.00007639614,0.0003246317,0.00004046051,0.00001013319,0.00006358281,0.00002485796,0.0009289398,0.9955569,0.0001165823,0.00001897287,0.001976292],"study_design_scores_gemma":[0.00002813851,0.001431192,0.00101791,0.000003139675,0.00001650714,0.00003627429,0.00001537769,0.0006160587,0.9963573,0.00002379267,0.0004481484,0.00000614002],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986017,0.0002543856,0.0002595028,0.00001026111,0.000004032578,0.00001019031,0.00009626289,0.000006241057,0.0007573382],"genre_scores_gemma":[0.9986057,0.0004687206,0.0003942964,0.00001482224,0.000002782393,0.00000818642,0.0001145693,0.000005585439,0.0003853797],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001133246,"threshold_uncertainty_score":0.003791034,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004829549222020305,"score_gpt":0.196782997039846,"score_spread":0.1919534478178257,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}