{"id":"W2478556254","doi":"10.1172/jci85939","title":"Local TNF causes NFATc1-dependent cholesterol-mediated podocyte injury","year":2016,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Renal Diseases and Glomerulopathies","field":"Medicine","cited_by":193,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Center for Advancing Translational Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; Leonard M. Miller School of Medicine; Institute of Genetics; National Institutes of Health; Waldemar von Frenckells Stiftelse; Novo Nordisk Fonden; Svenska Kulturfonden; Deutsche Forschungsgemeinschaft; American Heart Association; Halpin Foundation; University of Miami; Folkhälsanin Tutkimussäätiö; Wilhelm och Else Stockmanns Stiftelse; Nephcure Foundation; Samfundet Folkhälsan; F. Hoffmann-La Roche; University of Michigan; Novo Nordisk","keywords":"Podocyte; ABCA1; Albuminuria; Cholesterol; Endocrinology; Internal medicine; Medicine; Tumor necrosis factor alpha; Glomerulosclerosis; Kidney; Chemistry; Biochemistry; Transporter; Proteinuria","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001075443,0.0001535237,0.0006144845,0.0001534326,0.00004014359,0.00002715537,0.0001161449,0.0001934878,0.0001170514],"category_scores_gemma":[0.003491664,0.00008535067,0.0003445654,0.0001516546,0.0004306208,0.0003642266,0.00003636213,0.0003794103,0.0001334371],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006563246,"about_ca_system_score_gemma":0.0004333558,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000884305,"about_ca_topic_score_gemma":0.000004220097,"domain_scores_codex":[0.9970089,0.0002372597,0.001711244,0.0001852777,0.0006583519,0.000198967],"domain_scores_gemma":[0.9969947,0.0005782853,0.0009642149,0.0002160795,0.0005059346,0.0007408272],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003110741,0.0007244543,0.7859142,0.000196985,0.0004718904,0.0004005916,0.0001254451,0.00001543234,0.02163409,0.0003302601,0.01837162,0.1687042],"study_design_scores_gemma":[0.004193099,0.002834152,0.9734593,0.001200684,0.0003706017,0.0001850119,0.00006697932,0.00005797808,0.00861813,0.002682277,0.006165413,0.0001663891],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9886452,0.0004944124,0.001210384,0.00860848,0.000761701,0.0001237231,0.00002155742,0.00002570229,0.000108834],"genre_scores_gemma":[0.9937619,0.001389465,0.0002936947,0.003080856,0.001079323,0.000002267236,0.000007075224,0.00002023548,0.0003651769],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.187545,"threshold_uncertainty_score":0.41801,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05858555997973396,"score_gpt":0.3724486632723426,"score_spread":0.3138631032926086,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}