{"id":"W2478556254","doi":"10.1172/jci85939","title":"Local TNF causes NFATc1-dependent cholesterol-mediated podocyte injury","year":2016,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Renal Diseases and Glomerulopathies","field":"Medicine","cited_by":193,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Center for Advancing Translational Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; Leonard M. Miller School of Medicine; Institute of Genetics; National Institutes of Health; Waldemar von Frenckells Stiftelse; Novo Nordisk Fonden; Svenska Kulturfonden; Deutsche Forschungsgemeinschaft; American Heart Association; Halpin Foundation; University of Miami; Folkhälsanin Tutkimussäätiö; Wilhelm och Else Stockmanns Stiftelse; Nephcure Foundation; Samfundet Folkhälsan; F. Hoffmann-La Roche; University of Michigan; Novo Nordisk","keywords":"Podocyte; ABCA1; Albuminuria; Cholesterol; Endocrinology; Internal medicine; Medicine; Tumor necrosis factor alpha; Glomerulosclerosis; Kidney; Chemistry; Biochemistry; Transporter; Proteinuria","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002328206,0.0004244284,0.000375763,0.0002345617,0.0002010158,0.0003548915,0.0001305388,0.0002190933,0.001352357],"category_scores_gemma":[0.0001547063,0.000155198,0.0002950072,0.0001888552,0.0002897484,0.0002023302,0.000239173,0.0007196749,0.0004271702],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002318681,"about_ca_system_score_gemma":0.0001824642,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003819857,"about_ca_topic_score_gemma":0.0007897346,"domain_scores_codex":[0.9997267,0.00005589505,0.00003128674,0.00006495989,0.00006273299,0.00005834234],"domain_scores_gemma":[0.9998548,0.00001446611,0.00004185149,0.00002431687,0.00001552874,0.00004907333],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004666695,0.0000879508,0.001882545,0.0001007575,0.00001477763,0.0002149937,0.00003223327,0.00003065102,0.9948983,0.00003873256,0.00006846755,0.002163902],"study_design_scores_gemma":[0.0002069623,0.001614971,0.04046569,0.00003164323,0.00008303047,0.003862944,0.0001321653,0.001408991,0.947672,0.0001176798,0.004393891,0.00001006946],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940767,0.003189113,0.001472355,0.0001011407,0.00003820544,0.00002988673,0.0001553751,0.00004973357,0.0008875178],"genre_scores_gemma":[0.9963126,0.001164004,0.0009861785,0.00004766633,0.00002678579,0.00002853171,0.0002704523,0.000007230517,0.001156635],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001352357,"threshold_uncertainty_score":0.004524112,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05858555997973396,"score_gpt":0.3724486632723426,"score_spread":0.3138631032926086,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}