{"id":"W2478766160","doi":"10.1182/blood.v116.21.1416.1416","title":"Use of a Population Pharmacokinetic Model of ADVATE In Pediatric and Adult Patients with Hemophilia A Permits Limited Blood Sampling for Individual Dose Tailoring.","year":2010,"lang":"en","type":"article","venue":"Blood","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Medicine; Pharmacokinetics; Covariate; Population; Blood sampling; Sampling (signal processing); NONMEM; Internal medicine; Statistics; Mathematics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002457966,0.0004751794,0.0009454628,0.0001888924,0.0001278113,0.0006809923,0.0007928715,0.0006715466,0.001606512],"category_scores_gemma":[0.006845207,0.0004235771,0.0009192366,0.0002313447,0.0002617402,0.0005380248,0.0003430524,0.001336921,0.0003414065],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006325364,"about_ca_system_score_gemma":0.001253091,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006009261,"about_ca_topic_score_gemma":0.003491168,"domain_scores_codex":[0.9992108,0.0004983495,0.00002506912,0.000133098,0.00009027158,0.00004239511],"domain_scores_gemma":[0.9970405,0.00230619,0.0002958342,0.0001542601,0.0001538058,0.00004938871],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.001715923,0.0002438679,0.02858819,0.0001168951,0.0004636192,0.0003006376,0.0001658087,0.9372796,0.004430383,0.002418231,0.0008072791,0.02346948],"study_design_scores_gemma":[0.0001601168,0.0008182802,0.01003144,0.00001323199,0.0001745128,0.0001971492,0.00002460505,0.9844446,0.001449795,0.001070397,0.001589122,0.0000267266],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6618543,0.0004441685,0.3331184,0.0003342993,0.00002790146,0.0003815619,0.001417067,0.0002728515,0.002149366],"genre_scores_gemma":[0.9630018,0.0002609141,0.03334345,0.00008393668,0.00001477201,0.0004575839,0.001226893,0.00002763011,0.001582874],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006009261,"threshold_uncertainty_score":0.01299912,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05112765977615542,"score_gpt":0.2997104279348226,"score_spread":0.2485827681586671,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}