{"id":"W2478968180","doi":"10.1139/bcb-2016-0025","title":"FTY720P inhibits hepatic Na<sup>+</sup>–K<sup>+</sup> ATPase via S1PR2 and PGE2","year":2016,"lang":"en","type":"article","venue":"Biochemistry and Cell Biology","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Sphingosine; Ouabain; ATPase; Protein kinase C; Chemistry; Sphingosine-1-phosphate; Pertussis toxin; Prostaglandin E2; Calphostin; Receptor; Mechanism of action; Calphostin C; Agonist; Biochemistry; Molecular biology; Biology; Kinase; Enzyme; Endocrinology; Sodium; G protein","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001553831,0.0003632843,0.0004077915,0.0001773881,0.0001109847,0.0002428463,0.0001430977,0.0002895374,0.0008704566],"category_scores_gemma":[0.000109619,0.0001433357,0.0004127586,0.0001221766,0.0002472124,0.0002488246,0.0001574205,0.0004393443,0.0003610981],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002217697,"about_ca_system_score_gemma":0.0002296365,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006792432,"about_ca_topic_score_gemma":0.001162386,"domain_scores_codex":[0.999911,0.00001486722,0.00001129041,0.00001087966,0.00002215368,0.00002977592],"domain_scores_gemma":[0.9999465,0.000007961747,0.0000182997,0.000005618546,0.000007473794,0.00001404681],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001261858,0.00007524281,0.0002985977,0.0001629287,0.00001505206,0.0001644421,0.00002020403,0.00007637597,0.994335,0.00006187728,0.0001127141,0.003415685],"study_design_scores_gemma":[0.00009895347,0.001238869,0.0103111,0.00001114536,0.00004621409,0.0004893083,0.00007269617,0.001004609,0.9830748,0.00007520471,0.003569106,0.000008153454],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9882339,0.007217338,0.001882387,0.000341436,0.00006688943,0.00003486538,0.0002616558,0.0001413677,0.001820141],"genre_scores_gemma":[0.9914323,0.003298755,0.00159014,0.00009312257,0.00003741017,0.00004854708,0.0003664439,0.0000197018,0.003113526],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008704566,"threshold_uncertainty_score":0.002911985,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006024985404787553,"score_gpt":0.2101951810592504,"score_spread":0.2041701956544628,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}