{"id":"W2479570197","doi":"10.1128/jvi.01503-16","title":"NF-κB and IRF1 Induce Endogenous Retrovirus K Expression via Interferon-Stimulated Response Elements in Its 5′ Long Terminal Repeat","year":2016,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Chromosomal and Genetic Variations","field":"Agricultural and Biological Sciences","cited_by":119,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; McGill University; University of Winnipeg","funders":"Canadian Institutes of Health Research; Canada Foundation for Innovation; Manitoba Health Research Council; Manitoba Medical Service Foundation; ALS Association","keywords":"Biology; IRF1; Transcription factor; NFKB1; Interferon; Downregulation and upregulation; NF-κB; Cancer research; TANK-binding kinase 1; Tumor necrosis factor alpha; Interferon regulatory factors; Neuroinflammation; Endogenous retrovirus; Cell biology; IRF8; Immunology; HMGB1; Inflammation; Signal transduction; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002448336,0.0006182118,0.0001982349,0.0001669309,0.0001850275,0.0003077929,0.0003363392,0.0003635487,0.004386147],"category_scores_gemma":[0.0001802231,0.0001600826,0.0005598865,0.0001139488,0.000290222,0.0002948683,0.0003428233,0.0006740071,0.001480731],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003032008,"about_ca_system_score_gemma":0.0001793596,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001634722,"about_ca_topic_score_gemma":0.000199551,"domain_scores_codex":[0.9997422,0.00003941585,0.00001975971,0.00006136623,0.00006101162,0.00007623973],"domain_scores_gemma":[0.9998523,0.00002550049,0.00006145059,0.00001854504,0.00001590006,0.00002632355],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002990782,0.00007907917,0.0004708583,0.0001214556,0.000009657713,0.00007063278,0.00002258961,0.00005189537,0.9958428,0.0001629048,0.00008176467,0.002787386],"study_design_scores_gemma":[0.000063484,0.000717108,0.008358249,0.00005915724,0.00004568158,0.0009645953,0.0001176271,0.001691387,0.9799758,0.000285945,0.007709289,0.0000118766],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9744633,0.007821654,0.01096997,0.0002957484,0.0001824935,0.00007097529,0.0007525519,0.0003285854,0.005114689],"genre_scores_gemma":[0.9873486,0.001328317,0.004908699,0.000144613,0.00003330371,0.00006804324,0.001098679,0.00003887876,0.005030886],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004386147,"threshold_uncertainty_score":0.01467317,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02925797313655448,"score_gpt":0.2458195856858806,"score_spread":0.2165616125493261,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}