{"id":"W2479570197","doi":"10.1128/jvi.01503-16","title":"NF-κB and IRF1 Induce Endogenous Retrovirus K Expression via Interferon-Stimulated Response Elements in Its 5′ Long Terminal Repeat","year":2016,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Chromosomal and Genetic Variations","field":"Agricultural and Biological Sciences","cited_by":119,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; McGill University; University of Winnipeg","funders":"Canadian Institutes of Health Research; Canada Foundation for Innovation; Manitoba Health Research Council; Manitoba Medical Service Foundation; ALS Association","keywords":"Biology; IRF1; Transcription factor; NFKB1; Interferon; Downregulation and upregulation; NF-κB; Cancer research; TANK-binding kinase 1; Tumor necrosis factor alpha; Interferon regulatory factors; Neuroinflammation; Endogenous retrovirus; Cell biology; IRF8; Immunology; HMGB1; Inflammation; Signal transduction; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004771841,0.0001027955,0.0002023713,0.00004448004,0.00007176127,0.00001385266,0.0001633934,0.0001271403,0.0003391223],"category_scores_gemma":[0.00018881,0.0000346949,0.00004836592,0.0001069357,0.00004369314,0.0001154475,0.00009085249,0.0001446758,0.00001218398],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004213752,"about_ca_system_score_gemma":0.00001377468,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001343096,"about_ca_topic_score_gemma":0.00008284408,"domain_scores_codex":[0.9987544,0.0002986118,0.0004439388,0.0001620748,0.0001297093,0.0002113082],"domain_scores_gemma":[0.9991999,0.0003303325,0.0002661942,0.00004246332,0.00006439305,0.00009674278],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001350802,0.00008037285,0.02288456,0.000001285789,0.000008882896,0.0001683991,0.00008822574,0.000002339159,0.9498793,0.000001839915,0.00002655252,0.02550741],"study_design_scores_gemma":[0.001484667,0.004565124,0.8010577,0.0001120545,0.00002172604,0.001439876,0.00004187451,0.00004160437,0.1893231,0.0004279553,0.001321021,0.0001632614],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977992,0.000241187,0.00001887698,0.001675786,0.0001417686,0.00007785304,0.000009226372,0.000005640252,0.00003050195],"genre_scores_gemma":[0.9994335,0.00009640589,0.00007531173,0.0001345768,0.0001656441,0.000001948424,0.000001255131,9.986519e-7,0.00009033709],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7781731,"threshold_uncertainty_score":0.3713152,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02925797313655448,"score_gpt":0.2458195856858806,"score_spread":0.2165616125493261,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}