{"id":"W2479673743","doi":"10.1002/jbmr.2913","title":"Novel Genetic Variants Associated With Increased Vertebral Volumetric BMD, Reduced Vertebral Fracture Risk, and Increased Expression of <i>SLC1A3</i> and <i>EPHB2</i>","year":2016,"lang":"en","type":"article","venue":"Journal of Bone and Mineral Research","topic":"Bone health and osteoporosis research","field":"Medicine","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Aging","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Center for Advancing Translational Sciences; National Human Genome Research Institute; Johns Hopkins University; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; National Institute on Aging; National Institutes of Health; Hjartavernd; Novo Nordisk Fonden; Wake Forest University; Broad Institute; School of Medicine, Boston University","keywords":"Expression quantitative trait loci; Genome-wide association study; Single-nucleotide polymorphism; Osteoporosis; Quantitative computed tomography; Bone mineral; Minor allele frequency; Internal medicine; Bone density; Quantitative trait locus; Medicine; Biology; Genetics; Genotype; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004755423,0.0005440491,0.0003770406,0.0007299623,0.0003746875,0.0005668539,0.0004153132,0.0006514318,0.003523156],"category_scores_gemma":[0.001188997,0.0002063318,0.001273711,0.001164806,0.0002821357,0.0001099193,0.0002523084,0.0004888286,0.0002017917],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001938797,"about_ca_system_score_gemma":0.0002099291,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005430151,"about_ca_topic_score_gemma":0.00560114,"domain_scores_codex":[0.9995659,0.00008732063,0.00006209777,0.0001677907,0.00007309367,0.0000438663],"domain_scores_gemma":[0.9992502,0.0002623222,0.0003157991,0.00006423721,0.00004394305,0.00006346279],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00410985,0.0001371034,0.8871582,0.0002841717,0.005655007,0.003857262,0.0002047999,0.001170228,0.08240834,0.0005313925,0.001560384,0.01292324],"study_design_scores_gemma":[0.0003374663,0.0002184051,0.9856327,0.00005835192,0.003351885,0.002719025,0.00008236351,0.002286248,0.003773938,0.0004795028,0.001037301,0.00002288968],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956325,0.001299812,0.00120834,0.0001943703,0.00004095261,0.00001187932,0.001090692,0.00004705456,0.0004743436],"genre_scores_gemma":[0.9984193,0.0001780333,0.0005866258,0.00007809561,0.00003101284,0.000008254288,0.0004257048,0.000009811001,0.0002632085],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005430151,"threshold_uncertainty_score":0.0117861,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0282711558553111,"score_gpt":0.3155690877205931,"score_spread":0.287297931865282,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}