{"id":"W2480021183","doi":"10.1016/j.biopsych.2016.05.010","title":"Genome-wide Association for Major Depression Through Age at Onset Stratification: Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium","year":2016,"lang":"en","type":"article","venue":"Biological Psychiatry","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":217,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Janssen Biotech; National Institute on Drug Abuse; National Institute of Mental Health; Strategic Research Council; National Health and Medical Research Council; Australian Research Council; Roy J. and Lucille A. Carver College of Medicine, University of Iowa; Biotechnology and Biological Sciences Research Council; Stanley Center for Psychiatric Research, Broad Institute; University of North Carolina at Chapel Hill; Directorate for Biological Sciences; National Institutes of Health; H. Lundbeck A/S; Medical Research Council; Servier; Rheinische Friedrich-Wilhelms-Universität Bonn; Medical Research Council Canada; Centre Hospitalier Universitaire Vaudois; Göteborgs Universitet; Vetenskapsrådet; National Cancer Institute; Lundbeckfonden; Deutsche Forschungsgemeinschaft; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Queensland Brain Institute; Karolinska Institutet; University of Queensland; Queensland University of Technology; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; University of Glasgow; University of New England; Massachusetts Institute of Technology; European Science Foundation; King's College London; Chief Scientist Office; National Institute of Diabetes and Digestive and Kidney Diseases; Institut for Klinisk Medicin, Aarhus Universitet; King’s College London; Scottish Funding Council; Sanofi; Broad Institute; Wellcome Trust; Virginia Commonwealth University; National Institute on Alcohol Abuse and Alcoholism; Centre for Cognitive Ageing and Cognitive Epidemiology; University of Pittsburgh; QIMR Berghofer Medical Research Institute; Scottish Government; Ministry of Cultural Affairs; Philipps-Universität Marburg; University of Texas Southwestern Medical Center; Cardiff University; Centro de Investigación Biomédica en Red de Salud Mental; Eli Lilly and Company; Seventh Framework Programme; Kaiser Permanente; Vrije Universiteit Amsterdam; Stiftelsen för Strategisk Forskning; University of Dundee; European Commission; University of Aberdeen; Universidad del Atlántico; Massachusetts General Hospital; National Science Foundation; Wellcome; Aarhus Universitet; ZonMw; Strategiske Forskningsråd; GlaxoSmithKline; National Institute for Health and Care Research; Universidad de Granada; Aarhus Universitetshospital; National Center for Research Resources; National Alliance for Research on Schizophrenia and Depression; Menzies Centre for Australian Studies, King's College London, University of London; Florida Atlantic University; Chief Scientist Office, Scottish Government Health and Social Care Directorate; Institute of Psychiatry, Psychology and Neuroscience, King’s College London; Háskóli Íslands; Landspítali Háskólasjúkrahús; Bundesministerium für Bildung und Forschung; Institute of Genetics; Universität Greifswald; National Rosacea Society; Chinese Society of Clinical Oncology; Amgen; Pfizer","keywords":"Depression (economics); Genomics; Genome-wide association study; Psychiatry; Psychiatric genetics; Major depressive disorder; Association (psychology); Psychology; Medicine; Clinical psychology; Genome; Genetics; Biology; Genotype; Schizophrenia (object-oriented programming); Gene; Single-nucleotide polymorphism; Psychotherapist","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002716894,0.0004349697,0.0005372925,0.0008163085,0.0003724299,0.0005745285,0.0005491174,0.0004981089,0.001390853],"category_scores_gemma":[0.002658929,0.0001930449,0.000802558,0.001644011,0.0002114857,0.0001605942,0.0005677094,0.0006362812,0.0001684207],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003330723,"about_ca_system_score_gemma":0.0005553659,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007350178,"about_ca_topic_score_gemma":0.00852074,"domain_scores_codex":[0.9988821,0.0005493201,0.00008122107,0.0002939954,0.0001171667,0.00007623911],"domain_scores_gemma":[0.9989952,0.000221356,0.0003145329,0.0001839962,0.0001413111,0.0001435604],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009540243,0.00005826952,0.9795252,0.00009223135,0.00265305,0.0001722085,0.00007818209,0.000392609,0.003182886,0.0002483196,0.002181884,0.01046096],"study_design_scores_gemma":[0.0001527422,0.00009511068,0.9958946,0.00002187253,0.00127803,0.0002815221,0.00002788348,0.0005675842,0.0003219345,0.0003588228,0.0009919214,0.000008034319],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9768323,0.004989385,0.006095686,0.001060972,0.00009453156,0.0001631639,0.009107035,0.00007308547,0.00158385],"genre_scores_gemma":[0.9888378,0.001092124,0.003827628,0.0001552109,0.00006671269,0.0001359182,0.005342902,0.00002477775,0.0005168603],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007350178,"threshold_uncertainty_score":0.01461476,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01986392369211859,"score_gpt":0.2648426821577659,"score_spread":0.2449787584656473,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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