{"id":"W2480021183","doi":"10.1016/j.biopsych.2016.05.010","title":"Genome-wide Association for Major Depression Through Age at Onset Stratification: Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium","year":2016,"lang":"en","type":"article","venue":"Biological Psychiatry","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":217,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Janssen Biotech; National Institute on Drug Abuse; National Institute of Mental Health; Strategic Research Council; National Health and Medical Research Council; Australian Research Council; Roy J. and Lucille A. Carver College of Medicine, University of Iowa; Biotechnology and Biological Sciences Research Council; Stanley Center for Psychiatric Research, Broad Institute; University of North Carolina at Chapel Hill; Directorate for Biological Sciences; National Institutes of Health; H. Lundbeck A/S; Medical Research Council; Servier; Rheinische Friedrich-Wilhelms-Universität Bonn; Medical Research Council Canada; Centre Hospitalier Universitaire Vaudois; Göteborgs Universitet; Vetenskapsrådet; National Cancer Institute; Lundbeckfonden; Deutsche Forschungsgemeinschaft; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Queensland Brain Institute; Karolinska Institutet; University of Queensland; Queensland University of Technology; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; University of Glasgow; University of New England; Massachusetts Institute of Technology; European Science Foundation; King's College London; Chief Scientist Office; National Institute of Diabetes and Digestive and Kidney Diseases; Institut for Klinisk Medicin, Aarhus Universitet; King’s College London; Scottish Funding Council; Sanofi; Broad Institute; Wellcome Trust; Virginia Commonwealth University; National Institute on Alcohol Abuse and Alcoholism; Centre for Cognitive Ageing and Cognitive Epidemiology; University of Pittsburgh; QIMR Berghofer Medical Research Institute; Scottish Government; Ministry of Cultural Affairs; Philipps-Universität Marburg; University of Texas Southwestern Medical Center; Cardiff University; Centro de Investigación Biomédica en Red de Salud Mental; Eli Lilly and Company; Seventh Framework Programme; Kaiser Permanente; Vrije Universiteit Amsterdam; Stiftelsen för Strategisk Forskning; University of Dundee; European Commission; University of Aberdeen; Universidad del Atlántico; Massachusetts General Hospital; National Science Foundation; Wellcome; Aarhus Universitet; ZonMw; Strategiske Forskningsråd; GlaxoSmithKline; National Institute for Health and Care Research; Universidad de Granada; Aarhus Universitetshospital; National Center for Research Resources; National Alliance for Research on Schizophrenia and Depression; Menzies Centre for Australian Studies, King's College London, University of London; Florida Atlantic University; Chief Scientist Office, Scottish Government Health and Social Care Directorate; Institute of Psychiatry, Psychology and Neuroscience, King’s College London; Háskóli Íslands; Landspítali Háskólasjúkrahús; Bundesministerium für Bildung und Forschung; Institute of Genetics; Universität Greifswald; National Rosacea Society; Chinese Society of Clinical Oncology; Amgen; Pfizer","keywords":"Depression (economics); Genomics; Genome-wide association study; Psychiatry; Psychiatric genetics; Major depressive disorder; Association (psychology); Psychology; Medicine; Clinical psychology; Genome; Genetics; Biology; Genotype; Schizophrenia (object-oriented programming); Gene; Single-nucleotide polymorphism; Psychotherapist","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004446962,0.0002323811,0.0003058306,0.00002598682,0.000360158,0.00001249538,0.0004231891,0.0005807265,0.00003783407],"category_scores_gemma":[0.0007820887,0.000132015,0.0003177166,0.0001299934,0.0001436366,0.000005196487,0.0002003398,0.0001000717,0.000009243577],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009505315,"about_ca_system_score_gemma":0.00008334791,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001266065,"about_ca_topic_score_gemma":0.0002290108,"domain_scores_codex":[0.9979538,0.0002983708,0.0006200769,0.0005894298,0.000125015,0.0004133255],"domain_scores_gemma":[0.9981446,0.0003441317,0.0008142277,0.0005321153,0.0001023029,0.00006266277],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001523563,0.0001200637,0.9549755,0.0000107912,0.0001075344,7.849893e-8,0.00001353197,0.00001506167,0.03963593,0.0003194651,0.004312625,0.0003370191],"study_design_scores_gemma":[0.00130475,0.000192164,0.9627641,0.00001413977,0.00006879545,0.000002489452,0.00004278122,0.000003128985,0.001022968,0.006993583,0.02736308,0.000228028],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9813807,0.002690614,0.01001092,0.003425687,0.0009951888,0.0007314372,0.0001958148,0.00001876458,0.000550879],"genre_scores_gemma":[0.9898363,0.000494454,0.00716279,0.0008043289,0.0004436259,0.0001647366,0.0002429161,0.00002273751,0.0008281594],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03861296,"threshold_uncertainty_score":0.5383416,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01986392369211859,"score_gpt":0.2648426821577659,"score_spread":0.2449787584656473,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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