{"id":"W2480034218","doi":"10.1039/c6ra15373a","title":"Low generation anionic dendrimers modulate islet amyloid polypeptide self-assembly and inhibit pancreatic β-cell toxicity","year":2016,"lang":"en","type":"article","venue":"RSC Advances","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"PROTEO; Université du Québec à Montréal","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Dendrimer; Islet; Cytotoxicity; Chemistry; Peptide; Amyloid (mycology); Pancreatic islets; Toxicity; Biophysics; Cell biology; Biochemistry; Insulin; In vitro; Endocrinology; Biology; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001207358,0.0002654785,0.0001285365,0.0001025807,0.00008932532,0.0002898548,0.0001313834,0.000197781,0.0004826896],"category_scores_gemma":[0.000207666,0.00009219016,0.00007924611,0.00007097519,0.0001747852,0.0001914282,0.0001645979,0.0002976737,0.0001878443],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002453225,"about_ca_system_score_gemma":0.0001091029,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001688138,"about_ca_topic_score_gemma":0.0002926713,"domain_scores_codex":[0.9999342,0.00001271252,0.000006118128,0.00001026017,0.00001646688,0.00002030871],"domain_scores_gemma":[0.9999207,0.00001924604,0.00002798419,0.000007240375,0.00001111818,0.00001369461],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000738731,0.00001434936,0.0000644859,0.00001418257,0.000001128172,0.00001268596,0.00001023057,0.00007659868,0.9987048,0.00007008133,0.00002022263,0.0009375767],"study_design_scores_gemma":[0.00001116857,0.000118343,0.0003990796,0.00000166111,0.000003929072,0.00002536827,0.000005695266,0.0004409447,0.9984992,0.00002597804,0.0004666676,0.000002006906],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967387,0.0005386719,0.001510574,0.00004717594,0.00001364736,0.00001663641,0.00002588653,0.00004658744,0.001061994],"genre_scores_gemma":[0.9974366,0.0003764846,0.0007059497,0.00003039103,0.000004853865,0.00001456981,0.00003303563,0.00001384678,0.001384276],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004826896,"threshold_uncertainty_score":0.001779914,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01375560683591445,"score_gpt":0.2754824247990476,"score_spread":0.2617268179631331,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}