{"id":"W2480170620","doi":"10.1016/j.dadm.2016.07.002","title":"Assessing risk for preclinical β‐amyloid pathology with <i>APOE</i>, cognitive, and demographic information","year":2016,"lang":"en","type":"article","venue":"Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; Servier; Greta och Johan Kocks stiftelser; Vetenskapsrådet; Eisai; Northern California Institute for Research and Education; University of California, San Diego; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; Synarc; University of Southern California; Bristol-Myers Squibb; Eli Lilly and Company; Medpace; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Alzheimer's Association","keywords":"Medicine; Cohort; Disease; Demographics; Apolipoprotein E; Clinical trial; Cognition; Internal medicine; Pathology; Oncology; Psychiatry; Demography","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0009416523,0.0004150707,0.0004720408,0.0003408921,0.0004715052,0.0003582094,0.000140577,0.0001156345,0.0001071693],"category_scores_gemma":[0.0003452786,0.0002913664,0.0002164075,0.0002919531,0.0002853668,0.001885854,0.000175227,0.0002584968,0.00001635938],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004023907,"about_ca_system_score_gemma":0.0002991586,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001710838,"about_ca_topic_score_gemma":0.000002509192,"domain_scores_codex":[0.996793,0.0002687775,0.000669279,0.0006882153,0.0007978177,0.0007829166],"domain_scores_gemma":[0.9967338,0.001267838,0.0003614126,0.0003381867,0.0005942009,0.000704519],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004941549,0.000554146,0.7873264,0.00007279895,0.003082915,0.00003579824,0.00002937925,4.400781e-7,0.0002073535,0.00004113256,0.0001056295,0.2080499],"study_design_scores_gemma":[0.007178117,0.001013077,0.9700355,0.0009004871,0.01456001,0.000009834785,0.0003264667,0.00005459763,0.003755126,0.0001762599,0.001593963,0.0003965796],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9758208,0.006598086,0.01315379,0.001103169,0.0003056974,0.002490469,0.0001438516,0.0001386914,0.0002453923],"genre_scores_gemma":[0.9872467,0.00357234,0.004855905,0.0002423825,0.0002988091,0.003595883,0.0001268496,0.00005367334,0.000007470013],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2076533,"threshold_uncertainty_score":0.9999539,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0378327204356949,"score_gpt":0.3743525010894876,"score_spread":0.3365197806537927,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}