{"id":"W2480486994","doi":"10.1158/1538-7445.am2016-2961","title":"Abstract 2961: deBouganin conjugated to trastuzumab overcomes multiple mechanisms of T-DM1 drug resistance","year":2016,"lang":"en","type":"article","venue":"Cancer Research","topic":"Toxin Mechanisms and Immunotoxins","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Viventia Bio (Canada)","funders":"","keywords":"Trastuzumab; Saporin; Potency; In vitro; Epitope; In vivo; IC50; Biology; Pharmacology; Cytotoxicity; Immunotoxin; Molecular biology; Cancer research; Cancer; Antibody; Immunology; Biochemistry; Breast cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.001012608,0.0002206358,0.0004107447,0.0002877947,0.0002775231,0.00002149259,0.0006713631,0.0002232722,0.004144827],"category_scores_gemma":[0.0004121195,0.0001575376,0.0001093562,0.0003711538,0.0003052198,0.0001409108,0.0002061699,0.0004131006,0.0008881595],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000283618,"about_ca_system_score_gemma":0.0003124214,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009124839,"about_ca_topic_score_gemma":0.00120965,"domain_scores_codex":[0.9976487,0.0002840933,0.000444047,0.0005328058,0.0002081817,0.0008821559],"domain_scores_gemma":[0.9982078,0.0005977666,0.0001053727,0.0006164401,0.0003887347,0.00008387675],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007942986,0.0001080056,0.0001041896,0.0000410292,0.0001100443,0.000006850192,0.0004291741,0.000001034927,0.9760042,0.0062272,0.01199739,0.00417652],"study_design_scores_gemma":[0.001861517,0.000145842,0.003224098,0.0003127996,0.000007777066,0.000002298331,0.0003338421,1.816311e-7,0.9472145,0.002381821,0.04430518,0.0002101576],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896792,0.002670517,0.002125865,0.002225012,0.0008031629,0.0009642143,0.0003560523,0.00008066255,0.001095276],"genre_scores_gemma":[0.9736193,0.0002958824,0.0002765063,0.0001075929,0.0000320883,0.0002291702,0.00001280049,0.00004582145,0.02538088],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03230779,"threshold_uncertainty_score":0.9998898,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03603838800851163,"score_gpt":0.3258748728605611,"score_spread":0.2898364848520495,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}