{"id":"W2480533125","doi":"10.1016/j.biopha.2016.07.043","title":"Rosemary extract reduces Akt/mTOR/p70S6K activation and inhibits proliferation and survival of A549 human lung cancer cells","year":2016,"lang":"en","type":"article","venue":"Biomedicine & Pharmacotherapy","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":80,"is_retracted":false,"has_abstract":false,"ca_institutions":"Brock University","funders":"","keywords":"PI3K/AKT/mTOR pathway; Clonogenic assay; Protein kinase B; Apoptosis; Cancer research; A549 cell; Lung cancer; Cell growth; Cancer cell; Poly ADP ribose polymerase; Cancer; Biology; Pharmacology; Medicine; Chemistry; Oncology; Internal medicine; Biochemistry; Polymerase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001857392,0.000136557,0.0001460587,0.00007344566,0.00006942394,0.000009196589,0.0000436651,0.00009633078,0.00007466695],"category_scores_gemma":[0.000004015143,0.000091578,0.00002559428,0.00006542525,0.00009880183,0.00001510032,0.00001845577,0.00003253366,1.806904e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001352054,"about_ca_system_score_gemma":0.00003255453,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002713952,"about_ca_topic_score_gemma":0.000005205364,"domain_scores_codex":[0.9992154,0.00004527371,0.0002106457,0.0002628097,0.0001383647,0.0001275419],"domain_scores_gemma":[0.9996156,0.00001228034,0.0001403409,0.00009508454,0.0000689282,0.00006780414],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001367449,0.00004278581,0.001247134,0.00004116054,0.00004539785,3.117722e-7,0.0000818655,0.000001135821,0.9365873,0.00002086033,0.0006669682,0.06112835],"study_design_scores_gemma":[0.001841129,0.0002509411,0.00486622,0.00008696527,0.00002468177,0.000002465199,0.00001460078,0.00008610197,0.9882885,0.00002097808,0.004393017,0.0001243899],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941775,0.002731124,0.001924386,0.000561516,0.0002237286,0.0003058869,0.00001642002,0.00001056081,0.00004882977],"genre_scores_gemma":[0.9929181,0.00551976,0.00009872815,0.0001231234,0.0006087438,0.00002225876,0.00004235102,0.00002073538,0.0006462368],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06100396,"threshold_uncertainty_score":0.3734443,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01241571343308506,"score_gpt":0.3138812528743703,"score_spread":0.3014655394412852,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}