{"id":"W2481657687","doi":"10.5812/hepatmon.35953","title":"Heterozygous Inactivation of the Nuclear Receptor PXR/NR1I2 in a Patient With Anabolic Steroid-Induced Intrahepatic Cholestasis","year":2016,"lang":"en","type":"article","venue":"Hepatitis Monthly","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Universität des Saarlandes; Canadian Liver Foundation","keywords":"Pregnane X receptor; Cholestasis; Constitutive androstane receptor; Medicine; Nuclear receptor; Anabolic steroid; Bile acid; Internal medicine; Cholestyramine; Bile Salt Export Pump; Endocrinology; CYP3A4; Multidrug resistance-associated protein 2; Biology; Gene; Cytochrome P450; Anabolism; Genetics; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000294427,0.00143964,0.0006841479,0.001824509,0.001557654,0.0007647123,0.0006233832,0.002190832,0.002575421],"category_scores_gemma":[0.00142162,0.000661386,0.000530322,0.0008762964,0.001286373,0.0006237877,0.0007474372,0.001162371,0.0004681674],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005138771,"about_ca_system_score_gemma":0.0004656514,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001573109,"about_ca_topic_score_gemma":0.001490474,"domain_scores_codex":[0.999607,0.00004165543,0.0000469625,0.0001393481,0.00006146453,0.0001035365],"domain_scores_gemma":[0.9993669,0.0002169699,0.0001122954,0.0000428874,0.00003601218,0.00022485],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"case_report","study_design_scores_codex":[0.0001093165,0.00005825095,0.01742917,0.00002178685,0.0000113737,0.9761194,0.0003389901,0.00005852547,0.004257985,0.0001643035,0.0001791599,0.001251662],"study_design_scores_gemma":[0.0000202113,0.0001826234,0.01660458,0.00001010859,0.00002563551,0.9808699,0.0001523838,0.0002451278,0.001441276,0.0001275,0.0003076093,0.00001302618],"study_design_candidate":"case_report","study_design_consensus":"case_report","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946446,0.0005296809,0.0008843932,0.0007641314,0.0000714351,0.00005484991,0.000143296,0.00006099211,0.002846651],"genre_scores_gemma":[0.9989562,0.0001537919,0.0002542161,0.0001097295,0.00006926359,0.000005449396,0.00003954391,0.000009271504,0.0004024257],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002575421,"threshold_uncertainty_score":0.008615673,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04198835655938451,"score_gpt":0.3247240142313402,"score_spread":0.2827356576719557,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}