{"id":"W2481657687","doi":"10.5812/hepatmon.35953","title":"Heterozygous Inactivation of the Nuclear Receptor PXR/NR1I2 in a Patient With Anabolic Steroid-Induced Intrahepatic Cholestasis","year":2016,"lang":"en","type":"article","venue":"Hepatitis Monthly","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Universität des Saarlandes; Canadian Liver Foundation","keywords":"Pregnane X receptor; Cholestasis; Constitutive androstane receptor; Medicine; Nuclear receptor; Anabolic steroid; Bile acid; Internal medicine; Cholestyramine; Bile Salt Export Pump; Endocrinology; CYP3A4; Multidrug resistance-associated protein 2; Biology; Gene; Cytochrome P450; Anabolism; Genetics; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002623082,0.0002627344,0.0003576006,0.0001581262,0.0001336015,0.00001459345,0.0003334247,0.00019818,0.000360349],"category_scores_gemma":[0.00009321626,0.0001611736,0.00009192699,0.000402413,0.000168955,0.0001668298,0.0001171359,0.000367193,0.00003653578],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001430797,"about_ca_system_score_gemma":0.00008440347,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000673513,"about_ca_topic_score_gemma":0.0007481507,"domain_scores_codex":[0.9978201,0.0005901045,0.0005220626,0.0003470318,0.0002891857,0.0004314579],"domain_scores_gemma":[0.9988419,0.0001651777,0.0003418269,0.0003635834,0.0001278449,0.0001596231],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005888132,0.0006822514,0.1349938,0.00005219598,0.0001659647,0.00004295128,0.003208965,0.0002163956,0.5351806,0.000348647,0.0008215886,0.3236979],"study_design_scores_gemma":[0.006269169,0.0007513331,0.2920657,0.0002874919,0.0001912631,0.00002163862,0.0002333107,0.001816315,0.6400219,0.0003443755,0.05732416,0.0006733931],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959397,0.000219419,0.00001141501,0.0008603084,0.0007661873,0.0006803725,0.0001750501,0.00003952551,0.001307969],"genre_scores_gemma":[0.9978445,0.0006094532,0.0001089145,0.001151181,0.00008898513,0.0000957279,0.000005842461,0.00004652527,0.00004891501],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3230245,"threshold_uncertainty_score":0.6572471,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04198835655938451,"score_gpt":0.3247240142313402,"score_spread":0.2827356576719557,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}