{"id":"W2482156283","doi":"10.1158/1538-7445.am2016-4666","title":"Abstract 4666: Phosphatidylinositol 3-kinase (PI3K) and mTOR inhibitors demonstrate broad efficacy and synergy in head and neck cancer cell lines and patient-derived xenografts","year":2016,"lang":"en","type":"article","venue":"Cancer Research","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Saskatchewan Science Centre; University of Saskatchewan; Lunenfeld-Tanenbaum Research Institute; Ontario Institute for Cancer Research; Western University","funders":"","keywords":"Everolimus; PI3K/AKT/mTOR pathway; Cancer research; Medicine; Cancer; Kinase; Pharmacology; Biology; Oncology; Internal medicine; Signal transduction; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000363244,0.0003349878,0.000541907,0.0002293663,0.0001785176,0.0004099638,0.0002050194,0.0002862167,0.002422808],"category_scores_gemma":[0.0001880076,0.0001582823,0.0003096431,0.0003611827,0.0001620035,0.0002101907,0.0001700059,0.0007501995,0.0008201325],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002751602,"about_ca_system_score_gemma":0.000353339,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001240563,"about_ca_topic_score_gemma":0.002128936,"domain_scores_codex":[0.9997346,0.00005541292,0.0000341678,0.00004190381,0.00009237711,0.00004156748],"domain_scores_gemma":[0.9998229,0.00005597041,0.00002392466,0.00003214773,0.00002908091,0.00003594329],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001412213,0.0006436739,0.002760343,0.0001762074,0.00008392241,0.0001166365,0.00005062977,0.0006549871,0.9819922,0.000121181,0.001200637,0.01078724],"study_design_scores_gemma":[0.0002850672,0.00544299,0.02283282,0.00001692115,0.0001030215,0.001155732,0.00004504946,0.001852492,0.962913,0.00003942925,0.005301981,0.00001161587],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898155,0.003097116,0.001207341,0.0001367173,0.00004990364,0.00009446288,0.002289342,0.0001383166,0.003171305],"genre_scores_gemma":[0.9902949,0.001401012,0.002279566,0.00008375238,0.00001292536,0.00008481085,0.003455567,0.00003647888,0.002351067],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002422808,"threshold_uncertainty_score":0.008105099,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03189313237045931,"score_gpt":0.3788481480947124,"score_spread":0.3469550157242531,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}