{"id":"W2482331534","doi":"10.4049/jimmunol.1600526","title":"Accelerated Loss of TCR Repertoire Diversity in Common Variable Immunodeficiency","year":2016,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"University of Birmingham; Adaptive Biotechnologies; Wellcome Trust","keywords":"Common variable immunodeficiency; Repertoire; T-cell receptor; Diversity (politics); Biology; Immunology; Virology; Evolutionary biology; Immune system; Sociology; Antibody; T cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001701591,0.000218011,0.0006795815,0.0003044333,0.0003782073,0.000005336469,0.001372845,0.0002978287,0.0005921206],"category_scores_gemma":[0.000231318,0.000119894,0.0001622171,0.0004831008,0.00111731,0.0002684142,0.0005572159,0.0006008861,0.00006934803],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009500833,"about_ca_system_score_gemma":0.0001722498,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005590469,"about_ca_topic_score_gemma":0.000007818207,"domain_scores_codex":[0.997368,0.0008131522,0.001079539,0.0001507987,0.00008517364,0.0005033839],"domain_scores_gemma":[0.9976611,0.0005935542,0.0009185869,0.0005461573,0.0002749046,0.000005670031],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00180532,0.0005077564,0.007623338,0.00001135821,0.0003123435,0.00001404737,0.002345685,0.00005111782,0.9676589,0.001774459,0.0001030373,0.01779263],"study_design_scores_gemma":[0.02334962,0.003918206,0.338902,0.001185466,0.0004619996,0.004111485,0.009046594,0.000008525008,0.5848104,0.01283761,0.02025414,0.001113957],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9517383,0.04516564,0.0003309794,0.0006811905,0.001010565,0.0001280702,0.00001119535,0.00001534315,0.0009187165],"genre_scores_gemma":[0.9970466,0.002161271,0.00001340738,0.0000780776,0.000003324219,0.000001430255,0.000003244946,0.00001334979,0.0006792668],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3828485,"threshold_uncertainty_score":0.6483305,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01664505829742932,"score_gpt":0.2306343425107511,"score_spread":0.2139892842133218,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}