{"id":"W2482331534","doi":"10.4049/jimmunol.1600526","title":"Accelerated Loss of TCR Repertoire Diversity in Common Variable Immunodeficiency","year":2016,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"University of Birmingham; Adaptive Biotechnologies; Wellcome Trust","keywords":"Common variable immunodeficiency; Repertoire; T-cell receptor; Diversity (politics); Biology; Immunology; Virology; Evolutionary biology; Immune system; Sociology; Antibody; T cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001941226,0.0002177445,0.0002464261,0.0009440509,0.0001869117,0.0002829101,0.0001508653,0.0003529719,0.0007599982],"category_scores_gemma":[0.0004763785,0.0001265312,0.0001198708,0.000290214,0.0002695197,0.0001797133,0.0002628378,0.0003718967,0.00008871032],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000174755,"about_ca_system_score_gemma":0.00006836677,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003744799,"about_ca_topic_score_gemma":0.0004143268,"domain_scores_codex":[0.9998292,0.00003297526,0.00001476853,0.0000470628,0.00003440401,0.0000414878],"domain_scores_gemma":[0.9998036,0.0000486552,0.00006494209,0.00001877106,0.00001677734,0.00004720292],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0007709027,0.000069815,0.3694369,0.00006522024,0.00006712027,0.002723536,0.0004758405,0.0004612508,0.6061805,0.0001847207,0.0001979708,0.01936602],"study_design_scores_gemma":[0.000009904182,0.0002714422,0.9782698,0.000008672077,0.00001916533,0.01015028,0.0001008351,0.0005180428,0.009901755,0.0001856437,0.0005564375,0.000008054609],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991485,0.0003436283,0.0002422852,0.00001082479,0.000001753227,0.000002125258,0.00003308166,0.00001032093,0.0002074912],"genre_scores_gemma":[0.9995831,0.0001073708,0.0001562528,0.00001863264,0.000004299183,0.000002815362,0.00004472697,0.000002369981,0.0000804012],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009440509,"threshold_uncertainty_score":0.002542436,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01664505829742932,"score_gpt":0.2306343425107511,"score_spread":0.2139892842133218,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}