{"id":"W2482436688","doi":"10.1089/scd.2015.0383","title":"Modeling Nonalcoholic Fatty Liver Disease with Human Pluripotent Stem Cell-Derived Immature Hepatocyte-Like Cells Reveals Activation of PLIN2 and Confirms Regulatory Functions of Peroxisome Proliferator-Activated Receptor Alpha","year":2016,"lang":"en","type":"article","venue":"Stem Cells and Development","topic":"Lipid metabolism and biosynthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":117,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Stem Cell Network","keywords":"Biology; Nonalcoholic fatty liver disease; Peroxisome proliferator-activated receptor; Lipid metabolism; Induced pluripotent stem cell; Hepatocyte; Lipid droplet; Peroxisome; Cell biology; Fatty liver; Stem cell; Steatosis; Peroxisome proliferator-activated receptor alpha; Endocrinology; Nuclear receptor; Internal medicine; Cancer research; Receptor; Biochemistry; Disease; Transcription factor; Gene; In vitro; Embryonic stem cell","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002024596,0.0002696603,0.0001726544,0.0001480337,0.0000925566,0.0002383021,0.0001629229,0.0002102164,0.0009257045],"category_scores_gemma":[0.0001070101,0.0001371203,0.0002499545,0.0001051593,0.000151745,0.0001545587,0.0001741251,0.0004438527,0.0001917625],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001634903,"about_ca_system_score_gemma":0.0001495116,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003565261,"about_ca_topic_score_gemma":0.0004560094,"domain_scores_codex":[0.9998857,0.0000274162,0.00001126813,0.00001978234,0.00003997149,0.00001580429],"domain_scores_gemma":[0.9999419,0.00001178401,0.00001726146,0.0000105876,0.00000617132,0.00001216474],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001516276,0.00005795821,0.0006046449,0.00003823978,0.000008493091,0.00008992543,0.00002341127,0.001138109,0.995217,0.0003625065,0.00004767303,0.002260407],"study_design_scores_gemma":[0.00003668799,0.0006482466,0.001708088,0.000006119637,0.00003391008,0.0001756901,0.00003434093,0.005820916,0.988714,0.0001321892,0.002684473,0.000005361472],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9778684,0.001021209,0.01848028,0.0001225535,0.00005822436,0.00008033513,0.0003666251,0.0001240225,0.001878368],"genre_scores_gemma":[0.9907429,0.0006398638,0.006312576,0.00005816216,0.000006518156,0.00007033569,0.0004984298,0.00001657331,0.001654662],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009257045,"threshold_uncertainty_score":0.003096759,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01270860438835757,"score_gpt":0.1949350421091323,"score_spread":0.1822264377207747,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}