{"id":"W2482436688","doi":"10.1089/scd.2015.0383","title":"Modeling Nonalcoholic Fatty Liver Disease with Human Pluripotent Stem Cell-Derived Immature Hepatocyte-Like Cells Reveals Activation of PLIN2 and Confirms Regulatory Functions of Peroxisome Proliferator-Activated Receptor Alpha","year":2016,"lang":"en","type":"article","venue":"Stem Cells and Development","topic":"Lipid metabolism and biosynthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":117,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Stem Cell Network","keywords":"Biology; Nonalcoholic fatty liver disease; Peroxisome proliferator-activated receptor; Lipid metabolism; Induced pluripotent stem cell; Hepatocyte; Lipid droplet; Peroxisome; Cell biology; Fatty liver; Stem cell; Steatosis; Peroxisome proliferator-activated receptor alpha; Endocrinology; Nuclear receptor; Internal medicine; Cancer research; Receptor; Biochemistry; Disease; Transcription factor; Gene; In vitro; Embryonic stem cell","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001650484,0.0002694539,0.0003268294,0.00006848706,0.0001527155,0.00001951544,0.00009270765,0.0001575415,0.00001241614],"category_scores_gemma":[0.000001621744,0.0001757692,0.00004909158,0.00006356585,0.0001101225,0.00002053691,0.0000985478,0.00005855836,0.000001909565],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000249877,"about_ca_system_score_gemma":0.0001964905,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009790719,"about_ca_topic_score_gemma":0.000003454695,"domain_scores_codex":[0.9985705,0.00006467766,0.000426675,0.0004737165,0.0002354608,0.0002289415],"domain_scores_gemma":[0.9990793,0.00001595018,0.0002355899,0.0002712171,0.0002055995,0.0001923308],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005866092,0.0001212976,0.001116261,0.0002965974,0.0001098979,6.982235e-7,0.0003289799,0.00003247389,0.994306,0.000004991693,0.00004936507,0.003046827],"study_design_scores_gemma":[0.0009581294,0.0001013384,0.005335126,0.0002067602,0.0000405427,0.000001073566,0.000229339,0.00003024142,0.9903902,9.876998e-7,0.002425688,0.0002805662],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973686,0.0007239764,0.001209832,0.00002055489,0.00007909476,0.0004954432,0.00007545158,0.00001292311,0.0000140796],"genre_scores_gemma":[0.9978831,0.0003406999,0.0009154708,0.00003761256,0.00006622131,0.00004622299,0.00004279735,0.00002933567,0.0006385581],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004218865,"threshold_uncertainty_score":0.7167659,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01270860438835757,"score_gpt":0.1949350421091323,"score_spread":0.1822264377207747,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}