{"id":"W2482594761","doi":"10.1002/glia.23033","title":"TGFβ regulates persistent neuroinflammation by controlling Th1 polarization and ROS production via monocyte‐derived dendritic cells","year":2016,"lang":"en","type":"article","venue":"Glia","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"ASTER","funders":"Multiple Sclerosis Society; Uppsala Multidisciplinary Center for Advanced Computational Science; Schweizerische Multiple Sklerose Gesellschaft; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Experimental autoimmune encephalomyelitis; Biology; Immunology; Microglia; Neuroinflammation; Multiple sclerosis; Myeloid; Transforming growth factor; Monocyte; Cancer research; Cell biology; Inflammation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001106566,0.0002489727,0.0001557817,0.0001810473,0.00009828189,0.0002615472,0.00007010195,0.0001214397,0.0005030253],"category_scores_gemma":[0.00008661743,0.00009778429,0.0001087062,0.00009581746,0.0001758814,0.00009194609,0.0001478548,0.0003313627,0.0001968917],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001500554,"about_ca_system_score_gemma":0.000187329,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003643376,"about_ca_topic_score_gemma":0.0005994324,"domain_scores_codex":[0.9999188,0.00001769937,0.000005789124,0.00001272239,0.00001808378,0.00002683354],"domain_scores_gemma":[0.9999411,0.000004877458,0.00002504305,0.000004472249,0.000007504107,0.00001701296],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002604058,0.0000279628,0.001562495,0.00002598272,0.000006138951,0.00007844351,0.00002990744,0.00003338828,0.9950872,0.00006216356,0.00004375596,0.002782182],"study_design_scores_gemma":[0.000193425,0.0009722853,0.07841404,0.00004509715,0.0001036064,0.0009327541,0.0002478149,0.001943292,0.9107427,0.0005895952,0.005804741,0.00001062046],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958079,0.002293904,0.0008366271,0.00007463876,0.00002113017,0.00001058352,0.00009772634,0.00002925216,0.0008282695],"genre_scores_gemma":[0.9973423,0.001262367,0.000499108,0.0000353381,0.00001362549,0.00001082978,0.00007519321,0.00000669837,0.0007546156],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005030253,"threshold_uncertainty_score":0.001682818,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005848499389767862,"score_gpt":0.1851477540775252,"score_spread":0.1792992546877573,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}