{"id":"W2482594761","doi":"10.1002/glia.23033","title":"TGFβ regulates persistent neuroinflammation by controlling Th1 polarization and ROS production via monocyte‐derived dendritic cells","year":2016,"lang":"en","type":"article","venue":"Glia","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"ASTER","funders":"Multiple Sclerosis Society; Uppsala Multidisciplinary Center for Advanced Computational Science; Schweizerische Multiple Sklerose Gesellschaft; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Experimental autoimmune encephalomyelitis; Biology; Immunology; Microglia; Neuroinflammation; Multiple sclerosis; Myeloid; Transforming growth factor; Monocyte; Cancer research; Cell biology; Inflammation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002055653,0.0001423027,0.0001654451,0.00008649543,0.0002248517,0.0000254203,0.00006624922,0.0001615331,0.00006762338],"category_scores_gemma":[0.0001105356,0.0001098617,0.00005862709,0.0000636685,0.00009936171,0.0003455963,0.00002633388,0.00008261685,0.0002016453],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000047882,"about_ca_system_score_gemma":0.00001816491,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002237152,"about_ca_topic_score_gemma":0.000002869086,"domain_scores_codex":[0.9989805,0.0002104596,0.0002804782,0.0002644188,0.00003826874,0.0002258594],"domain_scores_gemma":[0.9994902,0.0000681187,0.0001447648,0.0001866595,0.00009353006,0.00001674354],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000269417,0.00002426883,0.0002191712,0.00001373773,0.00005479756,5.860734e-7,0.000212958,0.000009548725,0.988308,0.00005764941,0.000418093,0.01041174],"study_design_scores_gemma":[0.001362452,0.0001185256,0.002909904,0.00004791589,0.00005740722,0.00003644734,0.00006854175,0.0001184462,0.9919438,0.00009165591,0.003096561,0.0001483286],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936922,0.001696893,0.002168203,0.001281897,0.0006726853,0.0003570169,0.000006184785,0.00008574533,0.00003915178],"genre_scores_gemma":[0.9958429,0.0001782628,0.00003811326,0.00003160828,0.00004581251,0.00001782437,0.0000786591,0.0000153426,0.003751469],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01026342,"threshold_uncertainty_score":0.448003,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005848499389767862,"score_gpt":0.1851477540775252,"score_spread":0.1792992546877573,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}