{"id":"W2482863643","doi":"10.1038/ncomms12196","title":"Crystal structure of mammalian acid sphingomyelinase","year":2016,"lang":"en","type":"article","venue":"Nature Communications","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":93,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Research Council Canada; Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Western Economic Diversification Canada; Österreichischen Akademie der Wissenschaften; University of Saskatchewan; Canadian Light Source","keywords":"Acid sphingomyelinase; Sphingomyelin; Sphingomyelin phosphodiesterase; Cell biology; Ceramide; Protein structure; FERM domain; Biology; Chemistry; Biochemistry; Membrane protein; Integral membrane protein; Membrane","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009388317,0.0001000073,0.0001839085,0.0001257768,0.000109264,0.000007506778,0.0007034812,0.0002673769,0.0003624038],"category_scores_gemma":[0.0006699149,0.00006490716,0.00008887185,0.0003217138,0.0002686137,0.00008434142,0.0003208744,0.0006291904,0.00002243953],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000739397,"about_ca_system_score_gemma":0.0001298079,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002992455,"about_ca_topic_score_gemma":0.0003715913,"domain_scores_codex":[0.9990866,0.00007795286,0.0002035852,0.0001469739,0.0003036389,0.0001812826],"domain_scores_gemma":[0.9973773,0.0001274244,0.00006282484,0.001967381,0.0003499943,0.0001150198],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001084558,0.0001917479,0.02486605,0.00005131186,0.00006837349,0.000005986128,0.0002142023,2.117309e-7,0.9502285,0.008487632,0.003926099,0.01185144],"study_design_scores_gemma":[0.007138115,0.0006144347,0.3088006,0.0005932296,0.0002350985,0.0002675461,0.0006957465,0.0001062456,0.3501159,0.003418519,0.327376,0.0006385674],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9480205,0.009402479,0.0002061865,0.03462537,0.00009997324,0.0005611625,0.0002251233,0.00009302319,0.006766169],"genre_scores_gemma":[0.9936575,0.0002619211,0.005150098,0.0002205233,0.00004749671,0.000007704361,0.00005894633,0.00001997154,0.0005758329],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6001126,"threshold_uncertainty_score":0.3968068,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02372658049217977,"score_gpt":0.3358388430189038,"score_spread":0.3121122625267241,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}