{"id":"W2482863643","doi":"10.1038/ncomms12196","title":"Crystal structure of mammalian acid sphingomyelinase","year":2016,"lang":"en","type":"article","venue":"Nature Communications","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":93,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Research Council Canada; Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Western Economic Diversification Canada; Österreichischen Akademie der Wissenschaften; University of Saskatchewan; Canadian Light Source","keywords":"Acid sphingomyelinase; Sphingomyelin; Sphingomyelin phosphodiesterase; Cell biology; Ceramide; Protein structure; FERM domain; Biology; Chemistry; Biochemistry; Membrane protein; Integral membrane protein; Membrane","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003176556,0.0004931857,0.0007181123,0.000266232,0.0008962012,0.001235639,0.0009472566,0.0006822944,0.003870369],"category_scores_gemma":[0.0007608337,0.0003370392,0.0002419683,0.0006130251,0.0002774849,0.0005718414,0.0003336695,0.00188231,0.001097382],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001343979,"about_ca_system_score_gemma":0.001126636,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005478588,"about_ca_topic_score_gemma":0.005391764,"domain_scores_codex":[0.9997686,0.00003943768,0.00001120275,0.00004450803,0.00009355981,0.00004269312],"domain_scores_gemma":[0.9997754,0.00004577907,0.00002809237,0.0000111965,0.0000841627,0.00005543548],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004140442,0.001400099,0.01612572,0.001543039,0.0005035694,0.003511318,0.001426491,0.02894782,0.7466079,0.0246428,0.1016946,0.06945626],"study_design_scores_gemma":[0.002800704,0.001678502,0.05608923,0.0004651888,0.0005072484,0.004244879,0.002380546,0.2156246,0.250656,0.01627833,0.4489494,0.0003255433],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9089125,0.01963101,0.00997672,0.005138394,0.0008266887,0.0001968532,0.01288101,0.001091416,0.04134535],"genre_scores_gemma":[0.9147326,0.008744451,0.01601858,0.0009575108,0.000135375,0.0002320292,0.04407351,0.0002289239,0.01487701],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005478588,"threshold_uncertainty_score":0.01294768,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02372658049217977,"score_gpt":0.3358388430189038,"score_spread":0.3121122625267241,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}