{"id":"W2482951881","doi":"10.1158/1538-7445.am2016-2345","title":"Abstract 2345: SIRPαFc, a CD47-blocking cancer immunotherapeutic, triggers phagocytosis of lymphoma cells by both classically (M1) and alternatively (M2) activated macrophages","year":2016,"lang":"en","type":"article","venue":"Cancer Research","topic":"Phagocytosis and Immune Regulation","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Trillium Therapeutics (Canada)","funders":"","keywords":"CD47; Phagocytosis; CD80; CD14; Cancer research; Macrophage; Tumor microenvironment; Biology; CD16; CD11c; Immunology; Cell biology; Immune system; Chemistry; CD40; In vitro; Cytotoxic T cell; Phenotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001281401,0.0002516019,0.0001800169,0.0001182312,0.00008590442,0.0001511529,0.0001318094,0.0002705462,0.001476806],"category_scores_gemma":[0.00006823632,0.0000833844,0.0002020922,0.0000895118,0.0001145675,0.00009333932,0.0001057785,0.0004100576,0.0003420177],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001588589,"about_ca_system_score_gemma":0.000112454,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005091897,"about_ca_topic_score_gemma":0.0003356962,"domain_scores_codex":[0.9998771,0.00002572968,0.00001142614,0.00001591584,0.00002681223,0.00004299502],"domain_scores_gemma":[0.999948,0.00001369088,0.00001050713,0.000007251767,0.000005910586,0.0000145207],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003786731,0.00006719827,0.0001105665,0.00002580198,0.000003990582,0.00006111304,0.000008960989,0.00004164342,0.9984509,0.00005988251,0.00006936934,0.0007219331],"study_design_scores_gemma":[0.00003522749,0.0008409979,0.002190558,0.000003727301,0.000009963974,0.0002613254,0.00001435976,0.0005942698,0.994951,0.00001640476,0.001080632,0.000001505233],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968228,0.0008327371,0.0008882482,0.00007927787,0.00002680349,0.00002368368,0.0002053503,0.00002695154,0.001094124],"genre_scores_gemma":[0.9967372,0.0003518322,0.0007208113,0.00005580246,0.00001054716,0.00002526952,0.0003933858,0.000006644726,0.001698567],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001476806,"threshold_uncertainty_score":0.004940391,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04692771795007719,"score_gpt":0.3535585498625767,"score_spread":0.3066308319124995,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}