{"id":"W2483020535","doi":"10.1016/j.ebiom.2016.07.024","title":"HIV DNA Set Point is Rapidly Established in Acute HIV Infection and Dramatically Reduced by Early ART","year":2016,"lang":"en","type":"article","venue":"EBioMedicine","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":243,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"U.S. Military HIV Research Program; National Institute of Allergy and Infectious Diseases; Gilead Sciences; National Institute of Mental Health; Chulalongkorn University; ViiV Healthcare; Henry M. Jackson Foundation","keywords":"Human immunodeficiency virus (HIV); Peripheral blood mononuclear cell; Antiretroviral therapy; Medicine; Immunology; Viral load; Set point; DNA; Virology; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0002808287,0.0001666842,0.0002952489,0.0002357462,0.00006934308,0.00001460811,0.00008175483,0.0001642246,0.001628752],"category_scores_gemma":[0.0001130698,0.00009895164,0.00003460252,0.0002047883,0.0003433428,0.0001427906,0.000059061,0.0001662886,0.002620351],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007571941,"about_ca_system_score_gemma":0.00004661101,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009549919,"about_ca_topic_score_gemma":0.00001273763,"domain_scores_codex":[0.9987818,0.0001346858,0.0002780472,0.0003148786,0.00006631511,0.000424246],"domain_scores_gemma":[0.9994266,0.0001509486,0.00005435138,0.0002387414,0.00004445554,0.00008488086],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002581575,0.0001477325,0.01937242,0.00001271253,0.0002080097,0.00003668404,0.0006034437,3.314603e-9,0.637992,0.00002667939,0.3338642,0.007478015],"study_design_scores_gemma":[0.03324352,0.003983065,0.3470996,0.000602069,0.0002048317,0.0003676794,0.0001763123,0.000004048578,0.2544394,0.0008677419,0.3583911,0.0006205954],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9796993,0.0005573739,0.0003505927,0.01739425,0.0001751808,0.0003414924,0.0002618932,0.00005582023,0.001164142],"genre_scores_gemma":[0.9742755,0.0003709862,0.00005472667,0.0002982147,0.00003233051,0.00004661391,0.0004965096,0.00001475746,0.02441032],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3835526,"threshold_uncertainty_score":0.9992839,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007363382903573711,"score_gpt":0.254678170197208,"score_spread":0.2473147872936342,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}