{"id":"W2483020535","doi":"10.1016/j.ebiom.2016.07.024","title":"HIV DNA Set Point is Rapidly Established in Acute HIV Infection and Dramatically Reduced by Early ART","year":2016,"lang":"en","type":"article","venue":"EBioMedicine","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":243,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"U.S. Military HIV Research Program; National Institute of Allergy and Infectious Diseases; Gilead Sciences; National Institute of Mental Health; Chulalongkorn University; ViiV Healthcare; Henry M. Jackson Foundation","keywords":"Human immunodeficiency virus (HIV); Peripheral blood mononuclear cell; Antiretroviral therapy; Medicine; Immunology; Viral load; Set point; DNA; Virology; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003755548,0.0001861707,0.000390135,0.0003726832,0.0002772015,0.000598062,0.0001962288,0.000370304,0.00180677],"category_scores_gemma":[0.001120928,0.0002866425,0.0001216946,0.0002590476,0.0002722761,0.0003772774,0.0003327356,0.0006694681,0.0003433259],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002169259,"about_ca_system_score_gemma":0.0001549714,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004888775,"about_ca_topic_score_gemma":0.0005177734,"domain_scores_codex":[0.9997091,0.00005918302,0.00001957636,0.00005330784,0.00008798621,0.00007087848],"domain_scores_gemma":[0.999408,0.0001575862,0.0002250536,0.00005622039,0.00005427813,0.00009883184],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005429736,0.0006554857,0.5048865,0.000142654,0.00007804821,0.0005149367,0.0007308212,0.0003460399,0.4262357,0.0003608531,0.0003517669,0.06026735],"study_design_scores_gemma":[0.00003300845,0.002138246,0.9513749,0.00002293775,0.00003315092,0.00103319,0.0002625332,0.0004822848,0.0431033,0.0002535737,0.001249182,0.00001368519],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982387,0.0007170038,0.0003634547,0.00002069125,0.000003799653,0.00001518153,0.0001291767,0.00001422893,0.0004977711],"genre_scores_gemma":[0.998882,0.0002022268,0.0002889016,0.00002177072,0.00000903232,0.00002115247,0.0001877582,0.000003031057,0.000384125],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00180677,"threshold_uncertainty_score":0.006044209,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007363382903573711,"score_gpt":0.254678170197208,"score_spread":0.2473147872936342,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}