{"id":"W2483210912","doi":"10.1093/ije/dyw129","title":"Mendelian randomization study of adiposity-related traits and risk of breast, ovarian, prostate, lung and colorectal cancer","year":2016,"lang":"en","type":"article","venue":"International Journal of Epidemiology","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":164,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"Erasmus Medisch Centrum; ZonMw; Mayo Clinic; European Commission; National Institute of Environmental Health Sciences; National Institute for Health and Care Research; National Cancer Institute; National Institutes of Health; Cancer Research UK; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Wellcome Trust","keywords":"Mendelian randomization; Medicine; Oncology; Odds ratio; Body mass index; Breast cancer; Internal medicine; Genome-wide association study; Confounding; Prostate cancer; Confidence interval; Gynecology; Obstetrics; Cancer; Single-nucleotide polymorphism; Biology; Genetics; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002036276,0.0001051698,0.000463881,0.0001184332,0.00002708625,0.000002018686,0.0001403544,0.0001504666,0.00002149517],"category_scores_gemma":[0.002177248,0.00007019626,0.00007618059,0.00004514404,0.0001522593,0.000009446485,0.00007134525,0.00008524662,1.307834e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002231544,"about_ca_system_score_gemma":0.00006731068,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000191639,"about_ca_topic_score_gemma":0.0001202209,"domain_scores_codex":[0.9977946,0.0008448691,0.0009596724,0.000178029,0.00008995967,0.0001328196],"domain_scores_gemma":[0.9973583,0.0005818651,0.001374177,0.00005377487,0.0005664816,0.00006538146],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001244997,0.0001389707,0.9172132,0.000005412618,0.001503,0.000001791761,0.0001952915,0.0005543582,0.0643097,0.0001336647,0.0003844748,0.01431512],"study_design_scores_gemma":[0.006837491,0.0008139312,0.9889349,0.00004508397,0.0001840772,0.0001760894,0.00009866426,0.0002532518,0.00117216,0.001279087,0.0001218976,0.00008337021],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931597,0.001465778,0.003887126,0.0009732746,0.0002102694,0.0001631037,0.0001082275,0.00000143354,0.00003114994],"genre_scores_gemma":[0.9945086,0.004235484,0.001038679,0.00004950481,0.0001022792,0.000006836334,0.00000762414,0.00000781487,0.00004316552],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07172168,"threshold_uncertainty_score":0.2862521,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009232555293265002,"score_gpt":0.2936940335090465,"score_spread":0.2844614782157815,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}