{"id":"W2483485727","doi":"10.1038/srep30443","title":"Human DNA-Damage-Inducible 2 Protein Is Structurally and Functionally Distinct from Its Yeast Ortholog","year":2016,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; Grantová Agentura České Republiky; Ministerstvo Školství, Mládeže a Tělovýchovy; Canada Research Chairs","keywords":"Ubiquitin; Biology; Cell biology; Yeast; Protein domain; Protease; Saccharomyces cerevisiae; Tandem affinity purification; Computational biology; Genetics; Biochemistry; Gene; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004714709,0.0001691139,0.0001335764,0.00005095787,0.0003225187,0.000138601,0.0001276377,0.0001291568,0.0006189891],"category_scores_gemma":[0.0001432936,0.000119147,0.00006894991,0.00009194425,0.0002438542,0.00001489039,0.0001868458,0.00006228985,0.00003489658],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001203679,"about_ca_system_score_gemma":0.0001122828,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001437565,"about_ca_topic_score_gemma":0.00004991702,"domain_scores_codex":[0.9981682,0.00005043942,0.0003020941,0.0009463124,0.0002667882,0.0002661171],"domain_scores_gemma":[0.9988495,0.000004271044,0.0002005647,0.0006459086,0.0001615261,0.0001381899],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001083623,0.0000164379,0.005353477,0.000008922974,0.00001960322,0.00005615184,0.00003165928,1.372918e-7,0.9884211,0.00005220739,0.004375644,0.001653829],"study_design_scores_gemma":[0.0002019932,0.00007661206,0.0269697,0.00003437664,0.00001027833,0.00008590678,0.00001329558,9.482469e-7,0.9241214,0.003842771,0.04443696,0.0002056916],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961124,0.0001659319,0.0000827774,0.0002297473,0.0009471855,0.0003277904,0.00008322192,0.00002855575,0.002022362],"genre_scores_gemma":[0.9784487,0.000001595555,0.0002734186,0.00006116112,0.0002215766,0.00003767072,0.0001696978,0.00001836549,0.02076782],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06429963,"threshold_uncertainty_score":0.6777496,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01636998576918599,"score_gpt":0.2420388478285522,"score_spread":0.2256688620593662,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}