{"id":"W2483541584","doi":"10.1073/pnas.1609707113","title":"Leaky ryanodine receptors contribute to diaphragmatic weakness during mechanical ventilation","year":2016,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Respiratory Support and Mechanisms","field":"Medicine","cited_by":103,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute of Diabetes and Digestive and Kidney Diseases","keywords":"Ryanodine receptor; Mechanical ventilation; RYR1; Diaphragm (acoustics); Weakness; Diaphragmatic breathing; Medicine; Ventilation (architecture); Muscle weakness; Respiratory system; Respiratory failure; Pathophysiology; Anesthesia; Internal medicine; Receptor; Anatomy; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001115747,0.00008894241,0.0002063851,0.0001928653,0.0001228292,0.000009808668,0.0003141914,0.00007914199,0.0000858537],"category_scores_gemma":[0.0009489795,0.00004720426,0.00008678081,0.0005623898,0.0001869024,0.0002976531,0.0000979452,0.00007791127,0.000009339439],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005724296,"about_ca_system_score_gemma":0.00003899789,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":6.884774e-7,"about_ca_topic_score_gemma":3.166238e-8,"domain_scores_codex":[0.998125,0.000004698367,0.0003688497,0.0002175173,0.00111133,0.0001725866],"domain_scores_gemma":[0.9992354,0.00006344222,0.0002890421,0.00001038352,0.0003122621,0.00008945054],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000795365,0.00003173865,0.004175446,0.00006584269,0.00001274477,1.528163e-8,0.00004587407,0.000001544735,0.978046,0.01636898,0.0003390874,0.0008332137],"study_design_scores_gemma":[0.0004783187,0.0001034542,0.0513062,0.0003722011,0.00002211101,0.00001197856,0.00005898025,0.00002547205,0.9380721,0.008431142,0.001053721,0.00006426379],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920977,0.00002249169,0.00002691583,0.006610627,0.00006079646,0.0003165487,0.000007079371,0.00001780734,0.0008399843],"genre_scores_gemma":[0.9979646,0.000009678849,0.000891726,0.0002672212,0.0001060612,0.00001580307,1.041904e-7,0.000005266202,0.0007395762],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04713075,"threshold_uncertainty_score":0.1924934,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03506723937707512,"score_gpt":0.3078404646323824,"score_spread":0.2727732252553073,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}