{"id":"W2483585393","doi":"10.1039/c6qo00244g","title":"Synthesis and reactivity of alkoxy-activated cyclobutane-1,1-dicarboxylates","year":2016,"lang":"en","type":"article","venue":"Organic Chemistry Frontiers","topic":"Cyclopropane Reaction Mechanisms","field":"Chemistry","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Natural Sciences and Engineering Research Council of Canada; Eidgenössische Technische Hochschule Zürich; California Institute of Technology","keywords":"Cyclobutanes; Cyclobutane; Chemistry; Cycloaddition; Reactivity (psychology); Ring strain; Alkoxy group; Ring (chemistry); Strain (injury); Stereochemistry; Medicinal chemistry; Organic chemistry; Catalysis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00009316174,0.0002954659,0.0004244839,0.00002621099,0.0001252181,0.00003360933,0.0002349547,0.0002888665,0.003445493],"category_scores_gemma":[0.0004700399,0.0002406383,0.00009793544,0.0001440753,0.0002005116,0.0001432736,0.0001067931,0.0001735562,0.00001284609],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00026528,"about_ca_system_score_gemma":0.00009585745,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003081821,"about_ca_topic_score_gemma":0.000001287638,"domain_scores_codex":[0.9985091,0.00001447225,0.0003282694,0.0005223117,0.0002847729,0.0003410853],"domain_scores_gemma":[0.9987006,0.0001631015,0.0002888481,0.0005718662,0.00008432358,0.0001912344],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000799222,0.00005512174,0.001304444,0.0002202421,0.0001034368,0.0000087216,0.00004756944,6.907552e-8,0.9677274,0.000002385339,0.0003291715,0.03012157],"study_design_scores_gemma":[0.0004914274,0.000006632836,0.00008763189,0.0001332282,0.00008641838,0.0000676822,0.0006234563,0.000006101009,0.9896987,0.0001369723,0.008354239,0.0003074939],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9847617,0.0002974541,0.0004715643,0.0002301156,0.00008195854,0.00005506246,0.0000755449,0.0001944566,0.01383215],"genre_scores_gemma":[0.9966072,0.0003355975,0.0006079433,0.000006160823,0.00009274304,0.00001611155,0.000009359315,0.00006600704,0.002258923],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02981408,"threshold_uncertainty_score":0.9974655,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00492197500980707,"score_gpt":0.1832702890050095,"score_spread":0.1783483139952025,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}