{"id":"W2483834070","doi":"10.1016/s1470-2045(16)30173-5","title":"Radium-223 and concomitant therapies in patients with metastatic castration-resistant prostate cancer: an international, early access, open-label, single-arm phase 3b trial","year":2016,"lang":"en","type":"article","venue":"The Lancet Oncology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":291,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"Cilag; Johnson and Johnson","keywords":"Medicine; Prostate cancer; Concomitant; Clinical trial; Lymph node; Asymptomatic; Radium-223; Cancer; Internal medicine; Oncology; Surgery; Bone metastasis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001343993,0.00186997,0.003161265,0.0004274061,0.0004560237,0.001583665,0.000852919,0.001554545,0.004228812],"category_scores_gemma":[0.001213578,0.0007373833,0.002636676,0.0006600464,0.001168697,0.001179145,0.0005191307,0.004168437,0.00104252],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007669565,"about_ca_system_score_gemma":0.001273138,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009527212,"about_ca_topic_score_gemma":0.002370557,"domain_scores_codex":[0.9994349,0.0002927881,0.00002703552,0.00009915001,0.00004681608,0.00009929771],"domain_scores_gemma":[0.9993143,0.0001402707,0.0001633734,0.00006996145,0.00003115468,0.0002809172],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9260575,0.009361817,0.001744643,0.0006879948,0.002492025,0.00007585686,0.0001080837,0.001089848,0.005553288,0.0001683958,0.001835753,0.05082468],"study_design_scores_gemma":[0.8657936,0.1234729,0.005502321,0.00006160268,0.001320036,0.0001802647,0.00004802231,0.0008322475,0.0008063712,0.0002793789,0.00166042,0.0000428343],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9860243,0.00797617,0.0005615655,0.0008237193,0.0002960526,0.000881754,0.000839719,0.0001510493,0.002445575],"genre_scores_gemma":[0.9872121,0.004824197,0.001345107,0.00104009,0.0003196402,0.0009860791,0.001395718,0.00006659062,0.002810479],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004228812,"threshold_uncertainty_score":0.01414675,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1648475278424074,"score_gpt":0.447275284755596,"score_spread":0.2824277569131886,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}