{"id":"W2484023010","doi":"10.1371/journal.pone.0160255","title":"B Cell Receptor Activation Predominantly Regulates AKT-mTORC1/2 Substrates Functionally Related to RNA Processing","year":2016,"lang":"en","type":"article","venue":"PLoS ONE","topic":"14-3-3 protein interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Vetenskapsrådet; Sigrid Juséliuksen Säätiö; Stockholms Läns Landsting; University of Toronto; Cancerfonden; CRDF Global","keywords":"Phosphorylation; Biology; Protein kinase B; Cell biology; mTORC1; Proteomics; RNA splicing; Ribosomal protein s6; RNA-binding protein; RNA; Biochemistry; Molecular biology; Gene; P70-S6 Kinase 1","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001063657,0.0001582393,0.0001336068,0.00006740178,0.0001202623,0.00003790643,0.0001418471,0.0001685263,0.0002634038],"category_scores_gemma":[0.0003155776,0.0001288444,0.0000506619,0.0001349895,0.00004331096,0.00002569765,0.00005707542,0.00008368876,0.0002221996],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005626753,"about_ca_system_score_gemma":0.00009397198,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008373351,"about_ca_topic_score_gemma":0.000005578966,"domain_scores_codex":[0.9988787,0.00004274685,0.0002476237,0.0004016457,0.0002003307,0.0002289493],"domain_scores_gemma":[0.9991453,0.00003531088,0.0001360112,0.0002822384,0.0003043469,0.00009683491],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002175445,0.0003759582,0.0008078481,0.00003400002,0.00008380286,2.616453e-7,0.00004399606,0.000007985846,0.9947202,0.00002123595,0.002212044,0.001475182],"study_design_scores_gemma":[0.0004230733,0.0002882041,0.001646535,0.0002860588,0.00003212227,0.00000138859,0.00002971573,0.00000729261,0.9950195,0.0001492178,0.001916912,0.0001999986],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960042,0.0001293444,0.0006000146,0.001147709,0.00006852868,0.0003864254,0.00002033255,0.00005088753,0.00159255],"genre_scores_gemma":[0.9766468,0.00003338255,0.002756457,0.00008860024,0.000202717,0.0001331251,0.00007715895,0.00003909853,0.02002268],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01935743,"threshold_uncertainty_score":0.5254122,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01561890615688095,"score_gpt":0.2189740513067209,"score_spread":0.2033551451498399,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}