{"id":"W2484370973","doi":"10.1016/bs.mie.2016.01.012","title":"Synthesis and Assay of SIRT1-Activating Compounds","year":2016,"lang":"en","type":"article","venue":"Methods in enzymology on CD-ROM/Methods in enzymology","topic":"Sirtuins and Resveratrol in Medicine","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"National Institute on Aging; Glenn Foundation for Medical Research","keywords":"NAD+ kinase; Sirtuin 1; Enzyme; Sirtuin; Allosteric regulation; Biochemistry; DNA repair; Chemistry; Biology; Cell biology; Gene; Transcription factor; Downregulation and upregulation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005929933,0.001380778,0.0005741267,0.000915948,0.0005630812,0.0002162331,0.0009085624,0.0006768394,0.007606182],"category_scores_gemma":[0.0004735382,0.0005435717,0.0006390973,0.0009666253,0.0003043549,0.0004706985,0.0004539953,0.001574489,0.004328096],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000443931,"about_ca_system_score_gemma":0.0008705831,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005458312,"about_ca_topic_score_gemma":0.001593791,"domain_scores_codex":[0.999511,0.00008527576,0.00004414086,0.00009873557,0.0001417041,0.0001192614],"domain_scores_gemma":[0.9996501,0.00007032094,0.00003482816,0.00008914529,0.00008859093,0.00006705938],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003768794,0.0002185693,0.0001550915,0.0003225804,0.00004714531,0.000118382,0.00006812877,0.0007307405,0.9848247,0.0009431734,0.0007356729,0.01145883],"study_design_scores_gemma":[0.00003730375,0.0002202697,0.0001769173,0.00001009382,0.00001553934,0.000042521,0.000008691553,0.0002344488,0.9933999,0.0001501152,0.005694863,0.000009385441],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.4829228,0.01107909,0.4347115,0.0008193507,0.0007482033,0.004437621,0.01718307,0.003764365,0.04433396],"genre_scores_gemma":[0.6754221,0.00877064,0.2405445,0.0004585381,0.0001251356,0.003602583,0.0303759,0.0005131427,0.04018753],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007606182,"threshold_uncertainty_score":0.02544522,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06157094668535449,"score_gpt":0.4319569458566001,"score_spread":0.3703859991712456,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}