{"id":"W2485030690","doi":"10.1371/journal.pone.0159524","title":"Kupffer Cells Undergo Fundamental Changes during the Development of Experimental NASH and Are Critical in Initiating Liver Damage and Inflammation","year":2016,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Liver Disease Diagnosis and Treatment","field":"Medicine","cited_by":138,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; Cumming School of Medicine, University of Calgary; Canadian Institutes of Health Research; Alberta Innovates","keywords":"Steatohepatitis; Inflammation; Liver disease; Fatty liver; Kupffer cell; Macrophage; Liver injury; Biology; Alcoholic liver disease; Immunology; Cirrhosis; Medicine; Disease; Pathology; Endocrinology; Internal medicine; Genetics; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004108628,0.0002309053,0.0003220086,0.0004025865,0.0002359821,0.0004943986,0.0001380112,0.000349375,0.0009805551],"category_scores_gemma":[0.0002917147,0.0002287063,0.0001895547,0.000222846,0.0004095126,0.0004638344,0.0003649893,0.0007679947,0.0003784831],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002760637,"about_ca_system_score_gemma":0.0003137558,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005192571,"about_ca_topic_score_gemma":0.0008922673,"domain_scores_codex":[0.9997342,0.0000510324,0.00002496769,0.00004132099,0.00007870175,0.00006990099],"domain_scores_gemma":[0.9997951,0.00001908595,0.00007277535,0.00002160724,0.00003579316,0.00005566507],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0004926774,0.00003494453,0.004541,0.00007633417,0.000008372333,0.000288241,0.0001781582,0.00004905592,0.9886764,0.000436907,0.0000661841,0.005151805],"study_design_scores_gemma":[0.00005784804,0.001565998,0.1622692,0.0000852736,0.00006613634,0.00304409,0.001002781,0.0005647438,0.8149276,0.001282756,0.01509442,0.00003922726],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9829363,0.00976866,0.004248404,0.0003164199,0.00006692859,0.00005171367,0.000293974,0.0001193313,0.002198336],"genre_scores_gemma":[0.9911902,0.003246276,0.002752056,0.000125025,0.00002393707,0.00004996171,0.0002107382,0.00002069928,0.002380978],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009805551,"threshold_uncertainty_score":0.003280282,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05329686997101082,"score_gpt":0.2597580311458287,"score_spread":0.2064611611748179,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}