{"id":"W2485074482","doi":"10.1021/acs.biochem.6b00380","title":"Modulating Transmembrane α-Helix Interactions through pH-Sensitive Boundary Residues","year":2016,"lang":"en","type":"article","venue":"Biochemistry","topic":"Lipid Membrane Structure and Behavior","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Circular dichroism; Helix (gastropod); Peptide; Protein secondary structure; Transmembrane domain; Lipid bilayer; Biophysics; Transmembrane protein; Alpha helix; Membrane; Crystallography; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000188409,0.000229787,0.0001687248,0.0000731131,0.000109218,0.0002551667,0.0002012095,0.0002604354,0.001090948],"category_scores_gemma":[0.0002121601,0.0001378422,0.000161318,0.0000854035,0.0002190048,0.0002299079,0.0002290328,0.0005025201,0.0003666421],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001903302,"about_ca_system_score_gemma":0.0001230015,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001713807,"about_ca_topic_score_gemma":0.0002287288,"domain_scores_codex":[0.9998986,0.00002744206,0.00001183724,0.00002124284,0.00001871557,0.00002222097],"domain_scores_gemma":[0.9998332,0.00004534628,0.00005975881,0.00001374087,0.0000140737,0.00003390625],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008573202,0.00001608596,0.0000661487,0.00001600678,0.000001634559,0.00002116158,0.000007167309,0.00006260552,0.9992998,0.00004878471,0.000005949382,0.0003689505],"study_design_scores_gemma":[0.00004763711,0.0002476969,0.001097193,0.000005498138,0.000008022716,0.0001094908,0.00001181101,0.0006496223,0.9967306,0.0000403701,0.00104657,0.000005369759],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967877,0.0002084966,0.002080818,0.00005113787,0.0000156354,0.00004312845,0.00007093537,0.00003429279,0.0007078295],"genre_scores_gemma":[0.9958508,0.0002239316,0.003124388,0.00007061449,0.000005944757,0.00003121108,0.0001001062,0.00001364001,0.0005793098],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001090948,"threshold_uncertainty_score":0.003649592,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01153581300799976,"score_gpt":0.268145972176085,"score_spread":0.2566101591680852,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}