{"id":"W2485585585","doi":"10.1158/1538-7445.am2016-lb-205","title":"Abstract LB-205: Combination of DNA methyltransferase and PARP inhibitors as a novel therapy strategy for poor prognosis acute myeloid leukemia and triple-negative breast cancers","year":2016,"lang":"en","type":"article","venue":"Cancer Research","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Aging","funders":"","keywords":"Decitabine; PARP1; Azacitidine; PARP inhibitor; Cancer research; Triple-negative breast cancer; Poly ADP ribose polymerase; Olaparib; Breast cancer; Cancer; DNMT1; Myeloid leukemia; DNA damage; Biology; Chemistry; Methyltransferase; Polymerase; Medicine; DNA methylation; DNA; Internal medicine; Genetics; Methylation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001605218,0.0003363855,0.0004381836,0.0004417561,0.0001825888,0.0004272228,0.0004202079,0.0002670486,0.002352871],"category_scores_gemma":[0.000076779,0.0001072415,0.0003010701,0.0002357168,0.0001463905,0.0001683337,0.0002435215,0.000745604,0.0006580433],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002850463,"about_ca_system_score_gemma":0.0004325478,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008388362,"about_ca_topic_score_gemma":0.002489186,"domain_scores_codex":[0.9999399,0.0000117375,0.000004826341,0.000008841212,0.0000138714,0.00002086108],"domain_scores_gemma":[0.9999563,0.000004359443,0.000007312343,0.000003628036,0.000004258521,0.00002414396],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.008193961,0.005707735,0.003311259,0.0006148997,0.0002371248,0.001474411,0.00009638433,0.00228208,0.6432938,0.002845387,0.01158393,0.3203591],"study_design_scores_gemma":[0.008316194,0.08730146,0.0317982,0.0002047444,0.0009706819,0.01000766,0.0001600411,0.01168951,0.7040204,0.001088881,0.1443165,0.0001256671],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"other","genre_scores_codex":[0.9502097,0.0216889,0.005557826,0.001837388,0.0005318628,0.0004713724,0.0007934294,0.0006224484,0.01828712],"genre_scores_gemma":[0.9836114,0.00519897,0.00368065,0.0005678136,0.000132942,0.0001737214,0.0007215911,0.00002296543,0.00588986],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.002352871,"threshold_uncertainty_score":0.007871091,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09049719143922759,"score_gpt":0.4124340506577376,"score_spread":0.32193685921851,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}