{"id":"W2485813297","doi":"10.1016/j.jneuroim.2016.08.008","title":"Bi-phasic gliosis drives neuropathology in a Sandhoff disease mouse model","year":2016,"lang":"en","type":"article","venue":"Journal of Neuroimmunology","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research","keywords":"Astrogliosis; Gliosis; Sandhoff disease; Neuroscience; Excitotoxicity; Biology; Neurodegeneration; Neuropathology; Disease; Glutamate receptor; Medicine; Pathology; Receptor; Central nervous system; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003464456,0.001398886,0.0004269691,0.002164115,0.0006296565,0.000788009,0.0005116891,0.001217074,0.003276706],"category_scores_gemma":[0.0001894735,0.0005118135,0.0005396183,0.0005529159,0.0008871196,0.0006839865,0.0005982202,0.001806677,0.0008951899],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006009005,"about_ca_system_score_gemma":0.0004676223,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001331246,"about_ca_topic_score_gemma":0.004058821,"domain_scores_codex":[0.9994919,0.00008041319,0.0000804563,0.000114951,0.0001335243,0.0000986756],"domain_scores_gemma":[0.999386,0.00005783383,0.0002415069,0.00007443538,0.00003595785,0.0002043142],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004959362,0.0002858542,0.0004147304,0.00005412713,0.0000256549,0.0006199842,0.00005831095,0.0001518467,0.995995,0.0006630682,0.0002492407,0.0009861807],"study_design_scores_gemma":[0.0002820918,0.00142174,0.0116274,0.00006291942,0.0002158134,0.004000438,0.0002884825,0.004420611,0.9725544,0.00095198,0.00413081,0.00004330942],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927583,0.0006467653,0.002118389,0.0002638173,0.00009487031,0.0001008282,0.001127023,0.0003896536,0.002500306],"genre_scores_gemma":[0.9870551,0.0008103268,0.002848883,0.0001252468,0.00003480132,0.0001188442,0.0005549106,0.0001192834,0.008332491],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003276706,"threshold_uncertainty_score":0.01096165,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0288660241799823,"score_gpt":0.3048910370838681,"score_spread":0.2760250129038858,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}