{"id":"W2486104543","doi":"10.1002/ejoc.201600578","title":"<i>N</i>‐<i>tert</i>‐Butylsulfinyl‐3,3,3‐trifluoroacetaldimine: Versatile Reagent for Asymmetric Synthesis of Trifluoromethyl‐Containing Amines and Amino Acids of Pharmaceutical Importance","year":2016,"lang":"en","type":"article","venue":"European Journal of Organic Chemistry","topic":"Fluorine in Organic Chemistry","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Natural Science Foundation of China; Ikerbasque, Basque Foundation for Science; Hillman Foundation; Canadian Bee Research Fund","keywords":"Trifluoromethyl; Reagent; Chemistry; Enantioselective synthesis; Novelty; Combinatorial chemistry; Aldimine; Organic chemistry; Amino acid; Catalysis; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.002451931,0.0004250306,0.0009342105,0.000139187,0.00008567514,0.00001472104,0.0007805031,0.0002194452,0.001707612],"category_scores_gemma":[0.004161595,0.0003400859,0.0003312256,0.0004467487,0.0004994635,0.0001671444,0.0002380165,0.0006066943,0.000007440295],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000143788,"about_ca_system_score_gemma":0.0001816224,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":5.782255e-7,"about_ca_topic_score_gemma":1.506303e-7,"domain_scores_codex":[0.9965604,0.0003175452,0.001800889,0.0004245149,0.000392557,0.000504073],"domain_scores_gemma":[0.9944349,0.002565696,0.00164638,0.0004141474,0.0005001151,0.0004387855],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001075969,0.0003166634,0.01059624,0.0005952665,0.0005312006,0.0001272913,0.0001870769,0.000001405493,0.9407573,0.000007340368,0.002020635,0.04378356],"study_design_scores_gemma":[0.005172625,0.0003333055,0.001527058,0.0002249234,0.0006921731,0.0006115896,0.0001995796,0.00001863461,0.971848,0.00002006257,0.01902403,0.0003280886],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910128,0.003467486,0.0004868421,0.000769245,0.0004316329,0.000214384,0.0001527465,0.00003486683,0.00342997],"genre_scores_gemma":[0.9953731,0.001345327,0.001682937,0.0001142048,0.0006051453,0.000005207617,0.000005453285,0.0001001606,0.0007684313],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04345547,"threshold_uncertainty_score":0.9999051,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05619316260627236,"score_gpt":0.3435039426562206,"score_spread":0.2873107800499483,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}