{"id":"W2486151394","doi":"10.1158/1557-3125.rasonc14-a14","title":"Abstract A14: Transactivation of the Rho-guanine exchange factor ARHGEF2 by oncogenic K-RAS potentiates invasion-migration in pancreatic ductal adenocarcinoma.","year":2014,"lang":"en","type":"article","venue":"Molecular Cancer Research","topic":"Pituitary Gland Disorders and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Transactivation; Chromatin immunoprecipitation; Transcription factor; Biology; MAPK/ERK pathway; Promoter; Cancer research; Oncogene; Carcinogenesis; Anti-apoptotic Ras signalling cascade; Guanine nucleotide exchange factor; Kinase; Molecular biology; Cell biology; Signal transduction; Cell cycle; Cell; Gene; Gene expression; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000267136,0.0001389657,0.0002407305,0.0001722252,0.00008223061,0.00001538324,0.0001321562,0.00009059276,0.0002707573],"category_scores_gemma":[0.00009776039,0.00009603891,0.0001051976,0.0004313452,0.00008561427,0.00008544963,0.00002799591,0.0002666662,0.000008325567],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001632434,"about_ca_system_score_gemma":0.0001639215,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006239799,"about_ca_topic_score_gemma":0.001055954,"domain_scores_codex":[0.9983175,0.0001645814,0.0002412974,0.0002857189,0.0006742569,0.0003165804],"domain_scores_gemma":[0.9993384,0.00006738817,0.00006387677,0.0003166579,0.0001228335,0.00009083567],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003354191,0.0004599186,0.420846,0.0002344459,0.0001391912,0.00003527317,0.0006599259,0.00002816528,0.5722895,0.00002153524,0.0003624113,0.004588236],"study_design_scores_gemma":[0.002595337,0.000301124,0.8047686,0.0002181858,0.00005720484,0.000006388616,0.0001347308,0.0002578966,0.1911039,0.0002742276,0.0001747482,0.000107665],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919972,0.005133974,0.0001505239,0.001603513,0.00004517233,0.0006860456,0.00003840103,0.00001052842,0.0003346833],"genre_scores_gemma":[0.9988747,0.0005968945,0.00002429647,0.00008747301,0.00002859372,0.0001139567,0.00007850588,0.00002388972,0.0001717071],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3839226,"threshold_uncertainty_score":0.9432752,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03482556116131597,"score_gpt":0.3225340134829809,"score_spread":0.287708452321665,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}