{"id":"W2486151394","doi":"10.1158/1557-3125.rasonc14-a14","title":"Abstract A14: Transactivation of the Rho-guanine exchange factor ARHGEF2 by oncogenic K-RAS potentiates invasion-migration in pancreatic ductal adenocarcinoma.","year":2014,"lang":"en","type":"article","venue":"Molecular Cancer Research","topic":"Pituitary Gland Disorders and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Transactivation; Chromatin immunoprecipitation; Transcription factor; Biology; MAPK/ERK pathway; Promoter; Cancer research; Oncogene; Carcinogenesis; Anti-apoptotic Ras signalling cascade; Guanine nucleotide exchange factor; Kinase; Molecular biology; Cell biology; Signal transduction; Cell cycle; Cell; Gene; Gene expression; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001688354,0.0003217861,0.0002223793,0.000243683,0.0001436829,0.0001855338,0.0001633751,0.000205315,0.002677209],"category_scores_gemma":[0.00008111261,0.0001381434,0.0003814519,0.0001524975,0.0001827375,0.0001052069,0.0001698429,0.0006404302,0.0007991262],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002264732,"about_ca_system_score_gemma":0.0001731278,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005242671,"about_ca_topic_score_gemma":0.0008932375,"domain_scores_codex":[0.9997703,0.00004947333,0.00002050373,0.00003052161,0.00006892551,0.00006025991],"domain_scores_gemma":[0.9999073,0.00001935165,0.00001247697,0.00001170402,0.00001024589,0.0000389728],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001372253,0.000054647,0.00008890697,0.00002151348,0.000003695005,0.00004351353,0.000006550542,0.0000170927,0.9990191,0.0000315424,0.00007880312,0.0004974617],"study_design_scores_gemma":[0.00002895729,0.0005889215,0.005161187,0.000004408503,0.00001283512,0.0002232178,0.00001843186,0.0003733418,0.9911196,0.00001700108,0.002449448,0.000002668532],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"other","genre_scores_codex":[0.9940034,0.001100914,0.001461774,0.0001505279,0.00008273065,0.00003953547,0.0007365662,0.0001278492,0.002296729],"genre_scores_gemma":[0.9913585,0.000516939,0.001284264,0.00006227247,0.00001618757,0.00006297083,0.001837096,0.00002786846,0.004833926],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.002677209,"threshold_uncertainty_score":0.008956134,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03482556116131597,"score_gpt":0.3225340134829809,"score_spread":0.287708452321665,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}