{"id":"W2486369884","doi":"10.1200/jco.2016.34.15_suppl.6008","title":"BERIL-1: A phase II, placebo-controlled study of buparlisib (BKM120) plus paclitaxel in patients with platinum-pretreated recurrent/metastatic head and neck squamous cell carcinoma (HNSCC).","year":2016,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"","keywords":"Medicine; Paclitaxel; Placebo; Head and neck; Internal medicine; Basal cell; Head and neck squamous-cell carcinoma; Oncology; Chemotherapy; Head and neck cancer; Surgery; Cancer; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001388784,0.001568039,0.002517969,0.0006177003,0.0004311448,0.00100678,0.001297239,0.001616898,0.007198428],"category_scores_gemma":[0.001031919,0.000783126,0.000980906,0.0004077173,0.0009932952,0.001227655,0.0004491951,0.003166978,0.001597571],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007722622,"about_ca_system_score_gemma":0.001308796,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006111679,"about_ca_topic_score_gemma":0.002332603,"domain_scores_codex":[0.9995759,0.0002013299,0.00002285024,0.0000771581,0.00004089984,0.00008184499],"domain_scores_gemma":[0.9994703,0.00009790876,0.0001301858,0.00003162419,0.00003565515,0.0002343337],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8920061,0.03845764,0.001261952,0.001666328,0.0008741303,0.0000947154,0.0001024207,0.0008019609,0.01124753,0.0001509853,0.002791479,0.05054475],"study_design_scores_gemma":[0.8408874,0.1546166,0.00209006,0.00002966379,0.0002400904,0.00006927499,0.00002082946,0.0004295395,0.0006994845,0.00006205359,0.0008402563,0.00001478676],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9787239,0.006215231,0.0007350101,0.001010627,0.0004233959,0.00660877,0.002075556,0.0003529683,0.003854656],"genre_scores_gemma":[0.9782203,0.003826949,0.00191567,0.001593921,0.0004252831,0.006010225,0.002822971,0.00005277258,0.005131785],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007198428,"threshold_uncertainty_score":0.02408111,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0411726922846111,"score_gpt":0.3823928185052435,"score_spread":0.3412201262206324,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}