{"id":"W2486450281","doi":"10.1158/1538-7445.am2016-698","title":"Abstract 698: Progranulin targeting in urothelial cancer cells inhibits motility, tumor growth <i>in vitro</i> and <i>in vivo</i> and sensitizes cells to cisplatin","year":2016,"lang":"en","type":"article","venue":"Cancer Research","topic":"Glutathione Transferases and Polymorphisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Bladder cancer; Cancer research; Cancer; Cisplatin; Motility; Medicine; In vivo; Cancer cell; Cell growth; Tumor progression; Urothelial Cell; Tissue microarray; Biology; Internal medicine; Chemotherapy; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008529427,0.0004740691,0.0003140587,0.0002627682,0.0002142317,0.0002438175,0.0002746557,0.0003478641,0.004934193],"category_scores_gemma":[0.00006992203,0.000132043,0.0003505674,0.0002566005,0.0001917376,0.0001519104,0.0001520564,0.0007635087,0.001385628],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002793542,"about_ca_system_score_gemma":0.000444652,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001136984,"about_ca_topic_score_gemma":0.001318033,"domain_scores_codex":[0.9999075,0.00001149343,0.000009306673,0.00001476837,0.00003100695,0.00002595068],"domain_scores_gemma":[0.9999547,0.000006221231,0.000009212825,0.000006121405,0.000007519152,0.0000162904],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002434325,0.00009628508,0.0001632256,0.0001616082,0.0000123972,0.00009055617,0.00001524143,0.0001420996,0.9935318,0.0001515952,0.00120038,0.004191432],"study_design_scores_gemma":[0.00006017666,0.0007422609,0.002177406,0.00001487411,0.00002100992,0.0002789315,0.00001812179,0.0004606788,0.9885047,0.00004306842,0.007673398,0.000005437532],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9656802,0.007291616,0.005109577,0.001022166,0.0003570473,0.0002049461,0.004094581,0.000797428,0.01544245],"genre_scores_gemma":[0.9641864,0.00406643,0.004761138,0.0003190881,0.00004888803,0.0002498966,0.004978107,0.00006971476,0.0213203],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004934193,"threshold_uncertainty_score":0.01650649,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01823153655913561,"score_gpt":0.3062278980408381,"score_spread":0.2879963614817025,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}