{"id":"W2486450281","doi":"10.1158/1538-7445.am2016-698","title":"Abstract 698: Progranulin targeting in urothelial cancer cells inhibits motility, tumor growth <i>in vitro</i> and <i>in vivo</i> and sensitizes cells to cisplatin","year":2016,"lang":"en","type":"article","venue":"Cancer Research","topic":"Glutathione Transferases and Polymorphisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Bladder cancer; Cancer research; Cancer; Cisplatin; Motility; Medicine; In vivo; Cancer cell; Cell growth; Tumor progression; Urothelial Cell; Tissue microarray; Biology; Internal medicine; Chemotherapy; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008490268,0.0002007053,0.0002505475,0.0001821316,0.00006066488,0.00004422259,0.0001322297,0.0001255843,0.00004872521],"category_scores_gemma":[0.00004722222,0.0001641729,0.00003639035,0.0002703424,0.0001760114,0.0000132324,0.0001306196,0.0002636607,0.000005227876],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006768181,"about_ca_system_score_gemma":0.0001847001,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003592945,"about_ca_topic_score_gemma":0.003194218,"domain_scores_codex":[0.9979379,0.0001312242,0.0003296548,0.0006458536,0.0002607236,0.0006946986],"domain_scores_gemma":[0.9994265,0.000090482,0.00002935205,0.0001604162,0.00009304541,0.0002001755],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008113278,0.000059044,0.005518507,0.0001044758,0.000005806642,0.00005082728,0.0001892994,0.00002555733,0.9900305,0.000003815651,0.0004780858,0.002722737],"study_design_scores_gemma":[0.001626223,0.0001054833,0.003401662,0.000215279,0.000002449792,0.000002930867,0.00005804962,0.00001475242,0.9931964,0.00003832837,0.001143138,0.0001953226],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955416,0.002108203,0.00001081949,0.00118165,0.00008504184,0.0006814295,0.0002908709,0.000006700429,0.00009371994],"genre_scores_gemma":[0.9968984,0.002200291,0.0001115765,0.0002549728,0.0001579614,0.0001976272,0.000005009214,0.00003425086,0.0001399285],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003165864,"threshold_uncertainty_score":0.6694777,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01823153655913561,"score_gpt":0.3062278980408381,"score_spread":0.2879963614817025,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}