{"id":"W2486582555","doi":"10.1158/1538-7445.am2016-3792","title":"Abstract 3792: PAPSS1 (3’-phosphoadenosine 5’-phosphosulfate synthase 1) inhibition sensitizes non-small cell lung cancer to cisplatin treatment <i>in vivo</i>","year":2016,"lang":"en","type":"article","venue":"Cancer Research","topic":"Nitrogen and Sulfur Effects on Brassica","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Drug Research and Development; Izaak Walton Killam Health Centre","funders":"","keywords":"Cisplatin; In vivo; Transfection; Spheroid; Cancer research; Small hairpin RNA; Zebrafish; Gene silencing; Chemistry; A549 cell; Cell; Nude mouse; Cancer; Cell culture; Cell growth; Molecular biology; Biology; Apoptosis; In vitro; Chemotherapy; Medicine; Biochemistry; Internal medicine; Gene knockdown","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001313269,0.000477963,0.00044753,0.0002481664,0.0001941819,0.0002274735,0.0002748325,0.0003434704,0.004294168],"category_scores_gemma":[0.000088416,0.0001575648,0.0003792831,0.0002003914,0.0002375834,0.0001802943,0.0001393803,0.000708178,0.0009992194],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005323917,"about_ca_system_score_gemma":0.0004059956,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002081803,"about_ca_topic_score_gemma":0.00219073,"domain_scores_codex":[0.9998472,0.00001515234,0.00001500813,0.00003226353,0.00005598037,0.00003437755],"domain_scores_gemma":[0.999944,0.000008988514,0.00001489353,0.000007107097,0.000009619176,0.00001541504],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001527834,0.00004430588,0.00009305,0.00004981714,0.000005995708,0.00004438716,0.000008480476,0.00006639971,0.9978718,0.00006661447,0.0003545902,0.00124193],"study_design_scores_gemma":[0.00002772139,0.0004981529,0.001232804,0.000003912675,0.00001289484,0.0001353799,0.000009425855,0.0003846541,0.9947333,0.00001535676,0.002943332,0.000003021898],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9801161,0.003426356,0.004261542,0.0004827765,0.0002376079,0.0001576365,0.003808945,0.0006698637,0.006839103],"genre_scores_gemma":[0.9801979,0.001578022,0.002249796,0.00011423,0.00002327905,0.0001398242,0.004256203,0.00007470832,0.01136613],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004294168,"threshold_uncertainty_score":0.01436538,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01821803240087558,"score_gpt":0.325342509048043,"score_spread":0.3071244766471675,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}