{"id":"W2486671466","doi":"10.1200/jco.2013.31.15_suppl.lba2009","title":"Cilengitide combined with standard treatment for patients with newly diagnosed glioblastoma with <i>O<sup>6</sup>-methylguanine-DNA methyltransferase</i> (<i>MGMT</i>) promoter methylation: Final results of the multicenter, randomized, open-label, controlled, phase III CENTRIC study.","year":2013,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre","funders":"","keywords":"Medicine; Glioblastoma; Methyltransferase; Temozolomide; Oncology; Methylation; O-6-methylguanine-DNA methyltransferase; Internal medicine; Family medicine; Medical physics; Cancer research; DNA; Genetics; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004318499,0.0006127715,0.001567725,0.0005367753,0.0002592124,0.0005157777,0.0006209378,0.0005994427,0.002150854],"category_scores_gemma":[0.0005337325,0.0002730867,0.0008928844,0.0005581197,0.0004467418,0.0007923926,0.0002362097,0.001448588,0.0004814815],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009834362,"about_ca_system_score_gemma":0.0009892022,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002301995,"about_ca_topic_score_gemma":0.009243474,"domain_scores_codex":[0.999844,0.0000547515,0.00001334922,0.00002544145,0.00002354251,0.00003882482],"domain_scores_gemma":[0.9998494,0.00003124159,0.00003768377,0.00001071791,0.00001003982,0.0000608497],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.6695998,0.01170635,0.006025507,0.002458635,0.00295271,0.000270508,0.0001253052,0.001553381,0.01057639,0.000514898,0.01549103,0.2787255],"study_design_scores_gemma":[0.6708969,0.2547433,0.04733049,0.0003919366,0.003252028,0.0005629341,0.0002251842,0.003562152,0.004916029,0.001020561,0.01300399,0.00009450376],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9679307,0.02126534,0.0006711046,0.001571654,0.0009657586,0.001004052,0.001079693,0.0002354959,0.005276278],"genre_scores_gemma":[0.9829251,0.009822531,0.001142571,0.001074026,0.0003677764,0.0007185487,0.00201954,0.00002378596,0.001906036],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002301995,"threshold_uncertainty_score":0.007195354,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05012562409168991,"score_gpt":0.3811386982429238,"score_spread":0.3310130741512339,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}